Claudin 3 Antikörper

Produktnummer ABIN265362

Produktdetails anti-Claudin 3 Antikörper

Target: Claudin 3 (CLDN3)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Claudin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of Claudin-3 protein. (region surrounding Thr204)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity-Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: ELISA: 1/40000-1/60000. Western blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Claudin 3

Target: Claudin 3 (CLDN3)

Andere Bezeichnung: Claudin-3 / CLDN3 (CLDN3 Produkte)

Synonyme: claudin-3 antikoerper, cpe-r2 antikoerper, cpetr2 antikoerper, hrvp1 antikoerper, rvp1 antikoerper, CLDN3 antikoerper, LOC100228090 antikoerper, C7orf1 antikoerper, CPE-R2 antikoerper, CPETR2 antikoerper, HRVP1 antikoerper, RVP1 antikoerper, AI182374 antikoerper, Cpetr2 antikoerper, mRVP1 antikoerper, claudin 3 L homeolog antikoerper, claudin 3 antikoerper, claudin-4-like antikoerper, cldn3.L antikoerper, cldn3 antikoerper, CLDN3 antikoerper, LOC100228090 antikoerper, Cldn3 antikoerper

Hintergrund: The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and junction adhesion molecule (JAM). Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is highly restricted to specfic regions of different tissues and variations of Claudin expression may have an important role in transcellular transport through tight junctions. In rat liver, claudin-3 is uniformly expressed, whereas in the pancreas, claudin-3 is expressed in junctions of the duct epithelia and junctions of acinar cells. Claudin-3 binds the peptide toxin Clostridium perfringens enterotoxin (CPE) at the cell surface via the second extracellular loop of claudin-3. The gene encoding human claudin-3 maps to chromosome 7q11.23.Synonyms: C7orf1, CPE-R2, CPE-Receptor 2, CPETR2, Clostridium perfringens enterotoxin receptor 2, RVP1

Molekulargewicht: approx. 25 kDa

Gen-ID: 1365

NCBI Accession: NP_001297

UniProt: O15551

Pathways: Hepatitis C