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SRPRB Antikörper (AA 246-265)

SRPRB Reaktivität: Hund, Huhn WB, IHC (fro) Wirt: Schaf Polyclonal unconjugated
Produktnummer ABIN265297
  • Target Alle SRPRB Antikörper anzeigen
    SRPRB (Signal Recognition Particle Receptor, B Subunit (SRPRB))
    Bindungsspezifität
    • 10
    • 7
    • 7
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 246-265
    Reaktivität
    • 40
    • 8
    • 7
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Hund, Huhn
    Wirt
    • 38
    • 3
    • 3
    Schaf
    Klonalität
    • 42
    • 2
    Polyklonal
    Konjugat
    • 24
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SRPRB Antikörper ist unkonjugiert
    Applikation
    • 33
    • 20
    • 9
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    This antibody detects SRPR beta.
    Aufreinigung
    Purified
    Immunogen
    Synthetic peptide corresponding to amino acids 246-265 derived from the carboxyl terminal of the canine SRbeta subunit
    Isotyp
    IgG
    Top Product
    Discover our top product SRPRB Primärantikörper
  • Applikationshinweise
    Western blot: 1 to 5 μg/mL. Immunohistochemistry. Positive control: Canine microsomal protein.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Phosphate buffered saline with 0.08 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
  • Target
    SRPRB (Signal Recognition Particle Receptor, B Subunit (SRPRB))
    Andere Bezeichnung
    SR-beta (SRPRB Produkte)
    Synonyme
    wu:fk57h10 antikoerper, zgc:111820 antikoerper, zgc:92746 antikoerper, apmcf1 antikoerper, APMCF1 antikoerper, AA409543 antikoerper, Ab2-417 antikoerper, Ba1-667 antikoerper, Cc1-8 antikoerper, signal recognition particle receptor, B subunit antikoerper, SRP receptor beta subunit S homeolog antikoerper, SRP receptor beta subunit antikoerper, SRPRB antikoerper, srprb antikoerper, srprb.S antikoerper, Srprb antikoerper
    Hintergrund
    The receptor for Signal Recognition Particle (SRP) is the site on the endoplasmic reticulum that ribosomes translating secreted and integral membrane proteins are initially targeted to. Once the ribosome-SRP complex arrives at the SRP receptor the protein being translated is transferred to the translocation complex (Sec61) in the ER membrane. The SRP receptor is composed of two subunits SRalpha and SRbeta. The SRalpha subunit is a translocation GTPase peripherally bound to the endoplasmic reticulum by its interaction with SRbeta. SRalpha also binds to the GTPase of SRP (SRP54) and these two proteins appear to function as each others GTPase activating proteins (GAPs). Hydrolysis of GTP by SRalpha and SRP54 is thought to be involved in transfer of the nascent protein to the Sec61 complex in the ER. SRalpha has an apparent molecular weight of 72 kDa. SRbeta is a Type I transmembrane protein that spans the membrane once and contains Ras type GTPase domain. The function of the GTPase in SRbeta is unknown. The membrane spanning domain is at the amino-terminus of SRbeta. The GTPase domain encompasses three quarters of the protein and is carboxyl- of the transmembrane region. SRalpha binds to the GTPase domain of SRbeta. Heterodimerization of SRalpha and SRbeta masks the carboxyl-terminal epitope of SRbeta.Synonyms: APMCF1, PSEC0230, SR beta, SRPRB, Signal recognition particle receptor subunit beta
    Gen-ID
    58477
    NCBI Accession
    NP_067026
    UniProt
    Q9Y5M8
    Pathways
    ER-Nucleus Signaling
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