CERS6 Antikörper

Produktnummer ABIN265213

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CERS6 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für CERS6 Antikörper (ABIN265213)

Target: CERS6 (Ceramide Synthase 6 (CERS6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CERS6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CERS6 Antikörper

Spezifität: This antibody detects Lass6, widely expressed. Expressed in kidney, liver, brain, heart, placenta and lung.

Aufreinigung: Purified

Immunogen: Synthetic peptide dervied from human Lass6 protein

Anwendungsinformationen

Applikationshinweise: Western blot (5-7 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.

Details zu CERS6

Target: CERS6 (Ceramide Synthase 6 (CERS6))

Andere Bezeichnung: LASS6

Hintergrund: Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported, and the corresponding proteins have previously been investigated with respect to their key role in ceramide synthesis. However, members of the LAG family have been shown to be involved in cell growth regulation and cancer differentiation. May be involved in sphingolipid synthesis or its regulation. Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Localized to nuclear membrane a multi-pass membrane protein, may be expressed on endoplasmic reticulum membrane. Glycosylation on Asn-18 is not necessary for function. Like other LAG family members, the LASS6 protein contained a homeodomain and LAG1 domain. Lass6 displays highest homology to LASS5. The corresponding gene was localized to human chromosome 2q24.3, spanning a rather large genomic region of 318 kb. Sequences in mouse and zebrafish suggested a conservation of LASS6 in vertebrates because the protein and corresponding genomic sequences are highly conserved. LASS6 was shown to be broadly expressed in a wide range of tissues. Recent data suggested a role in cancer differentiation and early embryonic development.Synonyms: LAG1 longevity assurance homolog 6

Gen-ID: 253782

NCBI Accession: NP_982288

UniProt: Q6ZMG9