Netrin 1 Antikörper

Produktnummer ABIN265183

Produktdetails anti-Netrin 1 Antikörper

Target: Netrin 1 (NTN1)

Reaktivität: Human, Maus, Ratte, Affe, Rind (Kuh), Cat

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Netrin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects Netrin 1.

Aufreinigung: Affinity Chromatography.

Immunogen: Synthetic peptide derived from the human Netrin 1 protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot (0.05-0.5 μg/mL). Positive control: MDCKII cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.08 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at -20 °C. Can be shipped at 2-8 °C.

Details zu Netrin 1

Target: Netrin 1 (NTN1)

Andere Bezeichnung: Netrin-1 (NTN1 Produkte)

Hintergrund: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis. Netrin 1's main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.Synonyms: NTN1, NTN1L

Gen-ID: 9423

NCBI Accession: NP_004813

UniProt: O95631

Pathways: Regulation of Cell Size