TOLLIP Antikörper (C-Term)

Produktnummer ABIN265153

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TOLLIP in WB und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für TOLLIP Antikörper (C-Term) (ABIN265153)

Target: TOLLIP (Toll Interacting Protein (TOLLIP))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TOLLIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-TOLLIP Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody is specific for TOLLIP. Located in the cytoplasm and phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products (5).

Aufreinigung: Purified

Immunogen: A 16 amino acid peptide from near the carboxy terminus of human TOLLIP

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1 μg/mL. Positive Control: Rat Brain Lysate. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.

Details zu TOLLIP

Target: TOLLIP (Toll Interacting Protein (TOLLIP))

Andere Bezeichnung: TOLLIP

Hintergrund: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules to activate various kinases and transcription factors (3) so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation (4). This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.Synonyms: Toll-interacting protein

Gen-ID: 54472

NCBI Accession: NP_061882

UniProt: Q9H0E2