EDG4 Antikörper (N-Term)

Produktnummer ABIN265051

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch EDG4 in WB. Er zeigt eine Reaktivität gegenüber Human und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für EDG4 Antikörper (N-Term) (ABIN265051)

Target: EDG4 (LPAR2) (Lysophosphatidic Acid Receptor 2 (LPAR2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EDG4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-EDG4 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody recognizes Human EDG-4 / LPA2. Other species not tested.

Aufreinigung: Purified

Immunogen: Antibody raised against a unique synthetic peptide derived from the N-terminal of the human EDG4 protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 5 - 10 μg/mL, should be visualized using a high sensitivitysecondary/substrate system (i. e. Pierce's SuperSignal West Femto Maximum SensitivitySubstrate).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, 0.08 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Referenzen für anti-EDG4 Antikörper (ABIN265051)

Iwai, Koike, Ohshima, Miyatake, Uchiyama, Saeki, Ishii: "RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 22, Issue 10, pp. 1612-20, (2007) (PubMed).

Jayapal, Tay, Reghunathan, Zhi, Chow, Rauff, Melendez: "Genome-wide gene expression profiling of human mast cells stimulated by IgE or FcepsilonRI-aggregation reveals a complex network of genes involved in inflammatory responses." in: BMC genomics, Vol. 7, pp. 210, (2006) (PubMed).

Shida, Watanabe, Aoki, Hama, Kitayama, Sonoda, Kishi, Yamaguchi, Sasaki, Sako, Konishi, Arai, Nagawa: "Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 84, Issue 10, pp. 1352-62, (2004) (PubMed).

Details zu EDG4

Target: EDG4 (LPAR2) (Lysophosphatidic Acid Receptor 2 (LPAR2))

Andere Bezeichnung: EDG-4 / LPAR2

Hintergrund: EDG4 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG4 is lysophospholipid. There are 6 known members of the EDG receptor family and they are implicated in mediating growthrelated effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG4 is expressed in testes, ovarian tumor and leukocyte containing tissues.Synonyms: EDG4, Ipa-2, LPAR2, Lysophosphatidic acid receptor 2, Lysophosphatidic acid receptor Edg-4, endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4

Gen-ID: 9170

NCBI Accession: NP_004711

UniProt: Q9HBW0