RIT2 Antikörper

Produktnummer ABIN265015

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch RIT2 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für RIT2 Antikörper (ABIN265015)

Target: RIT2 (Ras-Like Without CAAX 2 (RIT2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RIT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RIT2 Antikörper

Spezifität: This antibody reacts to RIT2 (Rin).

Aufreinigung: Purified

Immunogen: His-tagged recombinant human Rin protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: detects recombinant Rin protein expressed in HEK-293 cells, Shows minimalcross-reactivity with Rit protein and other Ras proteins.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Details zu RIT2

Target: RIT2 (Ras-Like Without CAAX 2 (RIT2))

Andere Bezeichnung: RIT2

Hintergrund: Rit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated in spite of the fact that they lack a CAAX box or similar C-terminal lipidation motif. Rit and Rin display 64 % amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100 % conserved between the murine and human proteins. Although the effector domain sequences of Rit and Rin are very similar to that of Ras, Rit and Rin have been shown to interact with the known Ras-binding proteins RalGDS, Rlf and AF-6, but not the Raf kinases, RIN1 or the p110 subunit of PI3 kinase. For this reason, it has been suggested that Rit and Rin may play important roles in the regulation of signaling pathways distinct from those controlled by Ras.Synonyms: GTP-binding protein Rit2, RIN, ROC2, Ras-like protein expressed in neurons, Ras-like without CAAX protein 2

Gen-ID: 6014

NCBI Accession: NP_002921

UniProt: Q99578

Pathways: Neurotrophin Signalübertragung