TP53I3 Antikörper

Produktnummer ABIN265005

Der Kaninchen Polyklonal anti-TP53I3 Antikörper (ABIN265005) detektiert spezifisch TP53I3 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für TP53I3 Antikörper (ABIN265005)

Target: TP53I3 (Tumor Protein P53 Inducible Protein 3 (TP53I3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TP53I3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TP53I3 Antikörper

Spezifität: This antibody detects recombinant PIG-3 protein by Western blot.

Aufreinigung: Purified

Immunogen: Antibody developed using full-length recombinant PIG-3 protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot:
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, 0.08 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Details zu TP53I3

Target: TP53I3 (Tumor Protein P53 Inducible Protein 3 (TP53I3))

Andere Bezeichnung: TP53I3

Hintergrund: P53 inducible gene-3 (PIG-3) may be a long-lived reporter, which may be useful for detecting transient activation of p53. The p53 tumor suppressor is the most commonly mutated gene in human cancers. The p53 protein, which is stabilized in response to different biological checkpoints, is activated by DNA damage, hypoxia, viral infection, or oncogene activation resulting in efects such as cell cycle arrest, apoptosis, senescence, differentiation, and antiangiogenesis. Other genes also implicated in the downstream effects as a result of p53 activation are: p21WAF1, GADD45, 14-3-3, bax, Fas/APO1, KILLER/ DR5, Tsp1, IGF-BP3 and others. The p53-inducible gene 3 (PIG3), was recently identified in a screen for genes induced by p53 before the onset of apoptosis. PIG3 shares significant homology with the oxidoreductases from several species. PIG3 protein is localized to the cytoplasm and induced in primary, non-transformed, and transformed cell cultures after exposure to genotoxic agents. The induction of PIG3 by p53 occurrs with delayed kinetics as compared with other p53 downstream targets, such as p21 and MDM2. PIG3 levels are increased during p53-mediated growth arrest. Elevated levels of PIG3 are maintained in cells that resume cycling in the absence of ectopic p53 expression.Synonyms: PIG3, Quinone oxidoreductase PIG3, Tumor protein p53-inducible protein 3, p53-induced gene 3 protein

Gen-ID: 9540

NCBI Accession: NP_001193731

UniProt: Q53FA7

Pathways: p53 Signalweg