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S1PR1 Antikörper (C-Term)

S1PR1 Reaktivität: Human, Maus, Ratte WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN264982
  • Target Alle S1PR1 Antikörper anzeigen
    S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))
    Bindungsspezifität
    • 15
    • 11
    • 8
    • 7
    • 6
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 94
    • 59
    • 45
    • 8
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 92
    • 8
    Kaninchen
    Klonalität
    • 82
    • 18
    Polyklonal
    Konjugat
    • 53
    • 6
    • 6
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser S1PR1 Antikörper ist unkonjugiert
    Applikation
    • 77
    • 43
    • 15
    • 15
    • 14
    • 13
    • 12
    • 8
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Spezifität
    This antibody reacts to EDG1.
    Aufreinigung
    Purified
    Immunogen
    Synthetic peptide derived from the C-terminal of the EDG-1 receptor
    Isotyp
    IgG
    Top Product
    Discover our top product S1PR1 Primärantikörper
  • Applikationshinweise
    Western Blot: 5-10 μg/mL, Detects an approximately 44 kDa band in RH7777 cellstransfected with full length human EDG-1. Due to low expression of EDG receptors, werecommend use of Pierce Femto Signal substrate for western blot development.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Phosphate buffered saline with 0.08 % Sodium Azide as preservative.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
  • Zhang, Loyd, Randall, Waddell, Kriwacki, Ney: "A short linear motif in BNIP3L (NIX) mediates mitochondrial clearance in reticulocytes." in: Autophagy, Vol. 8, Issue 9, pp. 1325-32, (2013) (PubMed).

    Goparaju, Jolly, Watterson, Bektas, Alvarez, Sarkar, Mel, Ishii, Chun, Milstien, Spiegel: "The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation." in: Molecular and cellular biology, Vol. 25, Issue 10, pp. 4237-49, (2005) (PubMed).

    Matsushita, Morrell, Lowenstein: "Sphingosine 1-phosphate activates Weibel-Palade body exocytosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 31, pp. 11483-7, (2004) (PubMed).

    Toman, Payne, Watterson, Maceyka, Lee, Milstien, Bigbee, Spiegel: "Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension." in: The Journal of cell biology, Vol. 166, Issue 3, pp. 381-92, (2004) (PubMed).

    Yamaguchi, Kitayama, Takuwa, Arikawa, Inoki, Takehara, Nagawa, Takuwa: "Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells." in: The Biochemical journal, Vol. 374, Issue Pt 3, pp. 715-22, (2003) (PubMed).

    Cummings, Parinandi, Zaiman, Wang, Usatyuk, Garcia, Natarajan: "Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells." in: The Journal of biological chemistry, Vol. 277, Issue 33, pp. 30227-35, (2002) (PubMed).

    Graeler, Goetzl: "Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 16, Issue 14, pp. 1874-8, (2002) (PubMed).

  • Target
    S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))
    Andere Bezeichnung
    EDG-1 / S1PR1 (S1PR1 Produkte)
    Synonyme
    CD363 antikoerper, CHEDG1 antikoerper, D1S3362 antikoerper, ECGF1 antikoerper, EDG-1 antikoerper, EDG1 antikoerper, S1P1 antikoerper, AI849002 antikoerper, Edg1 antikoerper, Lpb1 antikoerper, S1p antikoerper, S1p1 antikoerper, S1P receptor 1 antikoerper, S1P receptor Edg-1 antikoerper, edg1 antikoerper, etID43307.22 antikoerper, s1p1 antikoerper, wu:fb98f05 antikoerper, s1pr1 antikoerper, xts1p1 antikoerper, sphingosine-1-phosphate receptor 1 antikoerper, sphingosine-1-phosphate receptor 1 L homeolog antikoerper, S1PR1 antikoerper, S1pr1 antikoerper, s1pr1 antikoerper, s1pr1.L antikoerper
    Hintergrund
    EDG-1 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-1 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-1 is expressed in cardiovascular, leukocytecontaining and other tissues.Synonyms: CHEDG1, D1S3362, ECGF1, EDG1, Endothelial differentiation G-protein coupled receptor 1, FLJ58121, S1P receptor 1, S1PR1, Sphingosine 1-phosphate receptor 1
    Gen-ID
    1901
    NCBI Accession
    NP_001391
    UniProt
    P21453
    Pathways
    Signaling Events mediated by VEGFR1 and VEGFR2
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