AKAP12 Antikörper (AA 620-1596)

Produktnummer ABIN264964

Dieser Schaf Polyklonal Antikörper detektiert spezifisch AKAP12 in WB, IP und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Ratte und Rind (Kuh).

Kurzübersicht für AKAP12 Antikörper (AA 620-1596) (ABIN264964)

Target: AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))

Reaktivität: Ratte, Rind (Kuh)

Wirt: Schaf

Klonalität: Polyklonal

Konjugat: Dieser AKAP12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-AKAP12 Antikörper

Bindungsspezifität: AA 620-1596

Aufreinigung: Ammonium Sulfate Precipitation.

Immunogen: Recombinant protein corresponding to amino acids 620-1596 of the SSeCKS protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 2-5 μg/mL. Immunoprecipitation. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline with 0.08 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Details zu AKAP12

Target: AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))

Andere Bezeichnung: AKAP12 / SSeCKS

Hintergrund: Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation and proliferation, yet little is known about downstream substrates or their roles in normal or diseased states. SSeCKS, a novel protein kinase C substrate originally isolated as a src-suppressed negative mitogenic regulator in fibroblasts, controls actinbased cytoskeletal architecture and scaffolds key signaling kinases such as protein kinase C and protein kinase A. Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation. A role for SSeCKS, a PKA/PKC scaffolding protein, has been implicatedduring the process of spermiogenesis and in the actinbased stellate morphology of mesangial cells.

Gen-ID: 10116

UniProt: Q62766

Pathways: cAMP Metabolic Process