AKAP12 Antikörper (AA 620-1596)

Produktnummer ABIN264964

Produktdetails anti-AKAP12 Antikörper

Target: AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))

Bindungsspezifität: AA 620-1596

Reaktivität: Ratte, Rind (Kuh)

Wirt: Schaf

Klonalität: Polyklonal

Konjugat: Dieser AKAP12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Aufreinigung: Ammonium Sulfate Precipitation.

Immunogen: Recombinant protein corresponding to amino acids 620-1596 of the SSeCKS protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 2-5 μg/mL. Immunoprecipitation. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline with 0.08 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Details zu AKAP12

Target: AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))

Andere Bezeichnung: AKAP12 / SSeCKS (AKAP12 Produkte)

Synonyme: akap12 antikoerper, cb27 antikoerper, esr1 antikoerper, fb72g12 antikoerper, id:ibd1202 antikoerper, sb:cb27 antikoerper, si:ch73-192g21.1 antikoerper, wu:fb72g12 antikoerper, wu:fc21c03 antikoerper, AKAP12 antikoerper, AI317366 antikoerper, SSeCKS antikoerper, Srcs5 antikoerper, Tsga12 antikoerper, AKAP12A antikoerper, AKAP12B antikoerper, AKAP12G antikoerper, AKAP250 antikoerper, A kinase (PRKA) anchor protein 12b antikoerper, A-kinase anchoring protein 12 antikoerper, A kinase (PRKA) anchor protein (gravin) 12 antikoerper, akap12b antikoerper, AKAP12 antikoerper, Akap12 antikoerper

Hintergrund: Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation and proliferation, yet little is known about downstream substrates or their roles in normal or diseased states. SSeCKS, a novel protein kinase C substrate originally isolated as a src-suppressed negative mitogenic regulator in fibroblasts, controls actinbased cytoskeletal architecture and scaffolds key signaling kinases such as protein kinase C and protein kinase A. Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation. A role for SSeCKS, a PKA/PKC scaffolding protein, has been implicatedduring the process of spermiogenesis and in the actinbased stellate morphology of mesangial cells.

Gen-ID: 10116

UniProt: Q62766

Pathways: cAMP Metabolic Process