Fibrinogen Antikörper

Produktnummer ABIN264639

Dieses Anti-Fibrinogen-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Fibrinogen in WB und EIA. Geeignet für Maus. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für Fibrinogen Antikörper (ABIN264639)

Target: Fibrinogen

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Fibrinogen Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-Fibrinogen Antikörper

Kreuzreaktivität (Details): Species reactivity (tested):Mouse.

Aufreinigung: Protein A Chromatography.

Immunogen: Native Mouse Fibrinogen.

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 17.0 mg/mL (OD280nm, E0.1% = 1.36)

Buffer: 0.05 M Sodium Phosphate, pH 6.6 containing 0.5 M Sodium Chloride and 1 mM EDTA, None

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody at -20 °C to -70 °C.

Referenzen für anti-Fibrinogen Antikörper (ABIN264639)

Fan, Xu, Wang, Luo, Zhu, Cai, Wei, Lu, Cao, Ye, Fan, Zhao: "Tissue Plasminogen Activator Neurotoxicity is Neutralized by Recombinant ADAMTS 13." in: Scientific reports, Vol. 6, pp. 25971, (2016) (PubMed).

Langhauser, Göb, Kraft, Geis, Schmitt, Brede, Göbel, Helluy, Pham, Bendszus, Jakob, Stoll, Meuth, Nieswandt, McCrae, Kleinschnitz: "Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation." in: Blood, Vol. 120, Issue 19, pp. 4082-92, (2012) (PubMed).

Details zu Fibrinogen

Target: Fibrinogen

Hintergrund: Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/mL. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.Synonyms: FGA, FGB, FGG