RIT1 Antikörper

Produktnummer ABIN264412

Dieses Maus Monoklonal-Antikörper erkennt spezifisch RIT1 in WB. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für RIT1 Antikörper (ABIN264412)

Target: RIT1 (Ras-Like Without CAAX 1 (RIT1))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RIT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 14G7

Produktdetails anti-RIT1 Antikörper

Spezifität: This antibody detects recombinant Rit protein expressed in 293 cells. Does not cross-react with Rin protein.

Produktmerkmale: Synonyms: RIBB, RIT, ROC1, Ras-like protein expressed in many tissues, Ras-like without CAAX protein1

Aufreinigung: Purified

Immunogen: Hybridoma produced by the fusion of splenocytes from mice immunized with recombinantfull-length human Rit protein and mouse myeloma cells. Genename: RIT1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot (0.5-1 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 20 mM Sodium phosphate, 150 mM Sodium Chloride, 50 % Glycerol at pH 7.5 and 3 mM Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.

Haltbarkeit: 12 months

Details zu RIT1

Target: RIT1 (Ras-Like Without CAAX 1 (RIT1))

Andere Bezeichnung: RIT1

Hintergrund: Rit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated in spite of the fact that they lack a CAAX box or similar C-terminal lipidation motif. Rit and Rin display 64 % amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100 % conserved between the murine and human proteins. Although the effector domain sequences of Rit and Rin are very similar to that of Ras, Rit and Rin have been shown to interact with the known Ras-binding proteins RalGDS, Rlf and AF-6, but not the Raf kinases, RIN1 or the p110 subunit of PI3 kinase. For this reason, it has been suggested that Rit and Rin may play important roles in the regulation of signaling pathways distinct from those controlled by Ras.Synonyms: RIBB, RIT, ROC1, Ras-like protein expressed in many tissues, Ras-like without CAAX protein 1

Gen-ID: 6016

UniProt: Q92963

Pathways: Neurotrophin Signalübertragung