TP53I3 Antikörper

Produktnummer ABIN264400

Dieser Maus Monoklonal Antikörper detektiert spezifisch TP53I3 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für TP53I3 Antikörper (ABIN264400)

Target: TP53I3 (Tumor Protein P53 Inducible Protein 3 (TP53I3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TP53I3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 10A2

Produktdetails anti-TP53I3 Antikörper

Spezifität: Recognizes PIG3 (p53 inducible gene 3).

Produktmerkmale: Synonyms: p53-induced gene 3 protein, PIG3, Tumor protein p53-inducible protein 3, Quinoneoxidoreductase PIG3

Aufreinigung: Purified

Immunogen: Hybridoma produced by the fusion of splenocytes from mice immunized with recombinanthuman PIG-3 protein. Genename: TP53I3

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot (5-10 μg/mL). Positive Control: Jurkat cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, 0.08 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.

Haltbarkeit: 12 months

Details zu TP53I3

Target: TP53I3 (Tumor Protein P53 Inducible Protein 3 (TP53I3))

Andere Bezeichnung: TP53I3

Hintergrund: P53 Inducible Gene-3 (PIG-3) may be a long-lived reporter, which may be useful for detecting transient activation of p53. The p53 tumor suppressor is the most commonly mutated gene in human cancers. The p53 protein, which is stabilized in response to different biological checkpoints, is activated by DNA damage, hypoxia, viral infection, or oncogene activation resulting in efects such as cell cycle arrest, apoptosis, senescence, differentiation, and antiangiogenesis. Other genes also implicated in the downstream effects as a result of p53 activation are: p21WAF1, GADD45, 14-3-3, bax, Fas/APO1, KILLER/ DR5, Tsp1, IGF-BP3 and others. The p53-inducible gene 3 (PIG3), was recently identified in a screen for genes induced by p53 before the onset of apoptosis. PIG3 shares significant homology with the oxidoreductases from several species. PIG3 protein is localized to the cytoplasm and induced in primary, non-transformed, and transformed cell cultures after exposure to genotoxic agents. The induction of PIG3 by p53 occurrs with delayed kinetics as compared with other p53 downstream targets, such as p21 and MDM2. PIG3 levels are increased during p53-mediated growth arrest. Elevated levels of PIG3 are maintained in cells that resume cycling in the absence of ectopic p53 expression.Synonyms: PIG3, Quinone oxidoreductase PIG3, Tumor protein p53-inducible protein 3, p53-induced gene 3 protein

Gen-ID: 9540

UniProt: Q53FA7

Pathways: p53 Signalweg