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AHNAK Antikörper (N-Term)

This anti-AHNAK antibody (ABIN263928) is a Mouse Monoclonal antibody detecting AHNAK in WB, IP, IHC (fro), IF. Suitable for Human, Mouse.
Produktnummer ABIN263928

Kurzübersicht für AHNAK Antikörper (N-Term) (ABIN263928)

Target

Alle AHNAK Antikörper anzeigen
AHNAK (AHNAK Nucleoprotein (AHNAK))

Reaktivität

  • 48
  • 3
  • 1
Human, Maus

Wirt

  • 33
  • 13
  • 2
Maus

Klonalität

  • 38
  • 10
Monoklonal

Konjugat

  • 24
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser AHNAK Antikörper ist unkonjugiert

Applikation

  • 18
  • 15
  • 13
  • 13
  • 8
  • 7
  • 7
  • 4
  • 4
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)

Klon

EM-09
  • Bindungsspezifität

    • 15
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term

    Spezifität

    The antibody reacts with AHNAK1, a 700 kDa multi-functional adaptor protein expressed mainly in epithelial cell, various types of muscle cells and immune cells.

    Kreuzreaktivität (Details)

    Species reactivity (tested):Human, Mouse.

    Produktmerkmale

    Synonyms: Desmoyokin, Neuroblast differentiation-associated protein AHNAK

    Aufreinigung

    Protein A Affinity Chromatography

    Immunogen

    Bacterially expressed fragment of N-terminal domain of human AHNAK1

    Isotyp

    IgG1
  • Applikationshinweise

    Immunohistochemistry on frozen sections. Western blot (Positive control: HeLa human cervix carcinoma cell line). Immunocytochemistry (Permeabilization is required, positive control: HeLa human cervixcarcinoma cell line). Immunoprecipitation.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1.0 mg/mL

    Buffer

    PBS, pH ~7.4, 15 mM Sodium Azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 to -80 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.

    Haltbarkeit

    12 months
  • Target

    AHNAK (AHNAK Nucleoprotein (AHNAK))

    Hintergrund

    AHNAK1 (Desmoyokin) is a large (700 kDa) scaffold protein that translocates to the plasma membrane after an increas of extracellular calcium level or upon proteinkinase C activation and regulates extracellular calcium influx mediated by L-type Ca2+ channels. AHNAK1 has been implicated in diverse signal transduction proceses affecting cell differentiation and proliferation. In response to calcium-dependent intercellular contacts AHNAK1 forms multimeric complexes in the plasma membrane, connected with actin and annexin 2/S100A10 assemblies and is thus involved in organization of the plasma membrane architecture. In epithelial cells, AHNAK1 is localized in cytoplasm or is membrane-associated, but in cells of nonepithelial origin AHNAK1 is predominantly nuclear, it has a weak DNA-binding activity and associates with the DNA-ligase IV-XRCC4 complex.Synonyms: Desmoyokin, Neuroblast differentiation-associated protein AHNAK

    Gen-ID

    79026

    UniProt

    Q09666
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