CD45.2 Antikörper (PE-Cy7)

Produktnummer ABIN2567775

Produktdetails anti-CD45.2 Antikörper (PE-Cy7)

Target: CD45.2 (CD45 (CD45.2 Allogen))

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD45.2 Antikörper ist konjugiert mit PE-Cy7

Applikation: Flow Cytometry (FACS)

Spezifität: The 104 monoclonal antibody specifically reacts with the mouse CD45 Molecule, the Leukocyte Common Antigen (LCA) which occurs in the alloantigen CD45.2-expressing mouse strains (C57BL/6, CBA, 129, A, AKR, C58, DBA/1, DBA/2, BALB/c, and C3H/He).

Aufreinigung: The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Klon: 104

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: Phosphate-buffered aqueous solution, ≤0.09 % Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Lagerung: 4 °C

Informationen zur Lagerung: The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.

Details zu CD45.2

Target: CD45.2 (CD45 (CD45.2 Allogen))

Andere Bezeichnung: CD45.2 (CD45.2 Produkte)

Hintergrund: The 104 monoclonal antibody specifically reacts with the MouseCD45 Molecule, the Leukocyte Common Antigen (LCA) which occurs in the alloantigen CD45.2-expressing Mousestrains (C57BL/6, CBA, 129, A, AKR, C58, DBA/1, DBA/2, BALB/c, and C3H/He). The 104 monoclonal antibody does not react with the leukocytes of the CD45.1-expressing Mousestrains (DA, SJL/J, RIII, and STS/A). The CD45 Molecule is a member of the Protein Tyrosine Phosphatase (PTP) family, because its intracellular region contains two PTP domains. The extracellular region's variability is caused by different levels of glycosylation, and the splicing of the 4, 5, and 6 exons. The isoforms found in the Mousestrains depend on the activation state, maturation stage and cell type, and are very important in B and T lymphocytes antigen receptor signal transduction. The 104 antibody inhibits some of the B lymphocytes responses, reduces the serum IgG levels, and influences the autoimmune renal pathology.

Gen-ID: 19264

UniProt: P06800