Amyloid Antikörper (APC)

Produktnummer ABIN2486477

Produktdetails

Target: Amyloid

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: APC

Applikation: ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: Recognizes all types of amyloid oligomers. Appears to recog a peptide backbone epitope common to amyloid oligomers, but not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.

Kreuzreaktivität: Eukaryonten, Human, Maus, Ratte

Aufreinigung: Protein A Purified

Immunogen: Synthetic molecular mimic of soluble oligomers

Anwendungsinformationen

Applikationshinweise:

• WB (1:200)
• IP (1:200)
• optimal dilutions for assays should be determined by the user.

Kommentare:

A 1:200 dilution of ABIN2486477 was sufficient for detection of amyloid oligomers in 10 μg of mouse brain lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Conjugated antibodies should be stored at 4°C

Antigendetails

Target: Amyloid

Synonyme: amyloid beta precursor protein antikoerper, App antikoerper

Hintergrund: Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).

Gen-ID: 8666

NCBI Accession: NM_000484

UniProt: P05067