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Versican Antikörper (AA 362-585) (PerCP)

Vcan Reaktivität: Maus WB, ICC, IF Wirt: Maus Monoclonal S351-23 PerCP
Produktnummer ABIN2485749
  • Target Alle Versican (Vcan) Antikörper anzeigen
    Versican (Vcan)
    Bindungsspezifität
    • 15
    • 14
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 362-585
    Reaktivität
    • 44
    • 37
    • 20
    • 4
    • 1
    • 1
    Maus
    Wirt
    • 44
    • 23
    • 1
    • 1
    Maus
    Klonalität
    • 39
    • 30
    Monoklonal
    Konjugat
    • 30
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Versican Antikörper ist konjugiert mit PerCP
    Applikation
    • 35
    • 17
    • 16
    • 16
    • 14
    • 13
    • 13
    • 9
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Spezifität
    Detects >350 kDa.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Fusion protein amino acids 362-585 (glycosaminoglycan alpha domain) of mouse Versican core protein
    Klon
    S351-23
    Isotyp
    IgG1
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  • Applikationshinweise
    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN2485749 was sufficient for detection of Versican in 20 μg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    Versican (Vcan)
    Andere Bezeichnung
    Versican (Vcan Produkte)
    Synonyme
    br146 antikoerper, cspg2 antikoerper, cspg2a antikoerper, sb:cb63 antikoerper, versican antikoerper, CSPG2 antikoerper, Cspg2 antikoerper, wgn antikoerper, ervr antikoerper, pg-m antikoerper, wgn1 antikoerper, Xversican antikoerper, dcan antikoerper, cspg2b antikoerper, fb99b07 antikoerper, wu:fb99b07 antikoerper, ERVR antikoerper, GHAP antikoerper, PG-M antikoerper, WGN antikoerper, WGN1 antikoerper, 5430420N07Rik antikoerper, 9430051N09 antikoerper, DPEAAE antikoerper, NG2 antikoerper, PG-M(V0) antikoerper, PG-M(V1) antikoerper, hdf antikoerper, versican a antikoerper, versican antikoerper, versican b antikoerper, vcana antikoerper, VCAN antikoerper, Vcan antikoerper, vcan antikoerper, vcanb antikoerper
    Hintergrund
    Versican (chondroitin sulfate proteoglycan 2) is a large extracellular matrix proteoglycan involved in cell growth and differentiation. Important as a structural molecule, versican creates loose and hydrated matrices during key events in development and disease. The protein contains hyaluronic acid and glycosminoglycan-binding domains, epidermal growth factor-like repeats, a Lectinlike sequence and a complement regulatory protein-like domain. Splice variants differ greatly in length anddegree of modification by glycoaminoglycan chains. Accumulation around smooth muscle cells in lesions of athero-sclerosis suggests a role for versican in atherogenesis. Versican, differentially expressed in human melanoma, plays a role in tumor development and may be a reliable marker for clinical diagnosis. The organization of HA- and versican-rich pericellular matrices may faciliatate migration and mitosis by diminishing cell surface adhesivity and affecting cell shape through steric exclusion and the viscous properties of HA proteoglycan gels.
    Gen-ID
    13003
    UniProt
    Q62059
    Pathways
    Glycosaminoglycan Metabolic Process
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