SPTBN4 Antikörper (AA 1621-1832) (FITC)

Produktnummer ABIN2485675

Der Maus Monoklonal anti-SPTBN4 Antikörper wird verwendet zum Nachweis von SPTBN4 in Proben von Human. Er wurde validiert für IHC, WB, ICC und IF.

Kurzübersicht für SPTBN4 Antikörper (AA 1621-1832) (FITC) (ABIN2485675)

Target: SPTBN4 (Spectrin Beta, Non-Erythrocytic 4 (SPTBN4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SPTBN4 Antikörper ist konjugiert mit FITC

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Klon: S393-2

Produktdetails anti-SPTBN4 Antikörper (FITC)

Bindungsspezifität: AA 1621-1832

Spezifität: Detects ~>200 kDa. Does not cross react with other Beta-spectrins

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Protein G Purified

Immunogen: Fusion protein amino acids 1621-1832 (C-terminal repeats 14 to 15) of human Beta4-spectrin

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

• WB (1:1000)
• optimal dilutions for assays should be determined by the user.

Kommentare:

A 1:100 dilution of ABIN2485675 was sufficient for detection of Beta 4 Spectrin in 20 μg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Conjugated antibodies should be stored at 4°C

Details zu SPTBN4

Target: SPTBN4 (Spectrin Beta, Non-Erythrocytic 4 (SPTBN4))

Andere Bezeichnung: beta 4 Spectrin

Hintergrund: Spectrin is the major constituent of the cytoskeletal network underlying the erthrocyte plasma membrane and determines cell shape, arrangement of transmembrane proteins and organization of organelles. It is expressed at very low levels in many tissues, with the strongest expression in the cerebellum, spinal cord, stomach, pituitary gland, liver, pancreas, salivary gland, kidney, bladder and heart (1). Spectrin beta 4 is a non-erythrocyte member, and is expressed in the brain and pancreatic islets and localisted to the nuclear matrix, cytoplasmic vesicles and PML nuclear bodies. Beta4 spectrins are also essential for membrane stability and the molecular organization of the nodes of Ranvier (2).

Gen-ID: 57731

NCBI Accession: NP_066022

UniProt: Q9H254

Pathways: Sensory Perception of Sound, Regulation of Actin Filament Polymerization, Maintenance of Protein Location