Erythrocyte Ankyrin Antikörper (AA 1-1881) (Biotin)

Produktnummer ABIN2485532

Dieses Anti-Erythrocyte Ankyrin-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Erythrocyte Ankyrin in WB, IHC, ICC und IF. Geeignet für Human.

Kurzübersicht für Erythrocyte Ankyrin Antikörper (AA 1-1881) (Biotin) (ABIN2485532)

Target: Erythrocyte Ankyrin (ANK1) (Ankyrin 1, Erythrocytic (ANK1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Erythrocyte Ankyrin Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Klon: S388A-10

Produktdetails anti-Erythrocyte Ankyrin Antikörper (Biotin)

Bindungsspezifität: AA 1-1881

Spezifität: Detects ~200 kDa. Does not cross-react with Ankyrin-B or Ankyrin-G.

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Protein G Purified

Immunogen: Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise:

• WB (1:1000)
• optimal dilutions for assays should be determined by the user.

Kommentare:

A 1:100 dilution of ABIN2485532 was sufficient for detection of Ankyrin R in 20 μg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Conjugated antibodies should be stored at 4°C

Details zu Erythrocyte Ankyrin

Target: Erythrocyte Ankyrin (ANK1) (Ankyrin 1, Erythrocytic (ANK1))

Andere Bezeichnung: Ankyrin R

Hintergrund: Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane. Ankyrin R, or Ank1, was first discovered in erythrocyres, but has since also been located in the brain and muscles. Mutations are associated with hereditary spehrocytosis and alzheimer's diease (2).

Gen-ID: 286

NCBI Accession: NP_000028

UniProt: P16157

Pathways: Synaptic Membrane