DLG4 Antikörper (Atto 390)

Produktnummer ABIN2484805

Produktdetails anti-DLG4 Antikörper (Atto 390)

Target: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DLG4 Antikörper ist konjugiert mit Atto 390

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Antibody Array (AA)

Spezifität: Detects ~100 kDa. An additional protein of >100 kDa is also detected. Additional cross-reactive bands are detected at ~75 kDa and 50 kDa in rat and mouse samples.

Kreuzreaktivität: Rind (Kuh), Human, Maus, Ratte

Aufreinigung: Protein G Purified

Immunogen: Recombinant rat PSD-95

Klon: 6G6

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

• WB (1:250)
• IHC (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Kommentare:

1 μg/ml was sufficient for detection of PSD-95 on 20 μg rat brain tissue extract by ECL immunoblot analysis using Goat Anti-Mouse IgG: HRP as the secondary.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Conjugated antibodies should be stored at 4°C

Details zu DLG4

Target: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Andere Bezeichnung: PSD95 (DLG4 Produkte)

Synonyme: 11 antikoerper, CG1725 antikoerper, CG1730 antikoerper, CPD antikoerper, DLG antikoerper, DLG-A antikoerper, Discs-large antikoerper, Dlg antikoerper, Dlg-A antikoerper, Dlg1 antikoerper, DlgA antikoerper, Dmel\\CG1725 antikoerper, Drodlg antikoerper, PSD95 antikoerper, SAP97 antikoerper, anon-EST:Posey93 antikoerper, anon-WO03040301.258 antikoerper, anon-WO03040301.260 antikoerper, anon-WO03040301.268 antikoerper, d. lg.-1 antikoerper, dlg antikoerper, dlg-1 antikoerper, dlg-A antikoerper, dlgA antikoerper, dlgS97 antikoerper, l(1)10Bf antikoerper, l(1)G0276 antikoerper, l(1)G0342 antikoerper, l(1)G0456 antikoerper, l(1)G19 antikoerper, l(1)L11 antikoerper, l(1)bwn antikoerper, l(1)d.lg-1 antikoerper, l(1)d.lg.-1 antikoerper, l(1)discs large antikoerper, l(1)dlg antikoerper, l(1)dlg-1 antikoerper, l(1)dlg1 antikoerper, l(1)l.pr.-2 antikoerper, l(1)lpr-2 antikoerper, misb antikoerper, dlgh4 antikoerper, psd95 antikoerper, sap90 antikoerper, sap-90 antikoerper, LLGL1 antikoerper, Dlgh4 antikoerper, PSD-95 antikoerper, SAP90 antikoerper, SAP90A antikoerper, Sap90 antikoerper, SAP-90 antikoerper, DLG4 antikoerper, discs large 1 antikoerper, discs, large homolog 4 antikoerper, discs large MAGUK scaffold protein 4 antikoerper, discs, large homolog 4b (Drosophila) antikoerper, discs, large homolog 4 (Drosophila) antikoerper, dlg1 antikoerper, dlg4 antikoerper, DLG4 antikoerper, dlg4b antikoerper, Dlg4 antikoerper

Hintergrund: Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90 kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex (1). These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins (2). Thus different PDZ domains of PSD-95 might be specialized for distinct functions (3, 4). PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) (5). The protein is implicated in experience dependent plasticity and plays an indispensable role in learning (6). Mutations in PSD95 are associated with autism (7).

Gen-ID: 29495

NCBI Accession: NP_062567

UniProt: P31016

Pathways: Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development, Asymmetric Protein Localization, Regulation of long-term Neuronal Synaptic Plasticity