Bassoon Antikörper (AA 786-1041) (Atto 488)

Produktnummer ABIN2484533

Dieses Anti-Bassoon-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Bassoon in IHC und WB. Geeignet für Human.

Kurzübersicht für Bassoon Antikörper (AA 786-1041) (Atto 488) (ABIN2484533)

Target: Bassoon (BSN)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Bassoon Antikörper ist konjugiert mit Atto 488

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Produktdetails anti-Bassoon Antikörper (Atto 488)

Bindungsspezifität: AA 786-1041

Spezifität: Detects ~420 kDa. Multiple isoforms can be detected.

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Protein A Purified

Immunogen: NM_003458.3 (AA 786-1041) N-terminal his-tagged fusion protein

Anwendungsinformationen

Applikationshinweise:

• WB (1:1000)
• IHC (1:400)
• optimal dilutions for assays should be determined by the user.

Kommentare:

1 μg/ml of ABIN2484533 was sufficient for detection of Bassoon in 10 μg of rat brain tissue lysate by colorimetric immunoblot analysis using goat ant rabbit IgG:HRP as the secondary antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Conjugated antibodies should be stored at 4°C

Details zu Bassoon

Target: Bassoon (BSN)

Andere Bezeichnung: Bassoon

Hintergrund: Bassoon is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntington, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to co-localize with GABA (A) and glutamate (GluR1) receptors (1).

Gen-ID: 8927

NCBI Accession: NP_003449

UniProt: Q9UPA5