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HCN2 Antikörper (AA 761-863) (APC)

HCN2 Reaktivität: Ratte WB, IHC, IP, IF, ICC, AA Wirt: Maus Monoclonal S71 APC
Produktnummer ABIN2481385
  • Target Alle HCN2 Antikörper anzeigen
    HCN2 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2))
    Bindungsspezifität
    • 10
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 761-863
    Reaktivität
    • 24
    • 21
    • 10
    • 1
    Ratte
    Wirt
    • 26
    • 12
    Maus
    Klonalität
    • 26
    • 12
    Monoklonal
    Konjugat
    • 20
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HCN2 Antikörper ist konjugiert mit APC
    Applikation
    • 29
    • 19
    • 15
    • 13
    • 13
    • 12
    • 10
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Antibody Array (AA)
    Spezifität
    Detects ~95 kDa. No cross-reactivity against HCN1.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Fusion protein amino acids 761-863 (cytoplasmic C-terminus) of rat HCN2
    Klon
    S71
    Isotyp
    IgG1
    Top Product
    Discover our top product HCN2 Primärantikörper
  • Applikationshinweise
    • WB (1:1000)
    • IHC (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN2481385 was sufficient for detection of HCN2 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    HCN2 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2))
    Andere Bezeichnung
    HCN2 (HCN2 Produkte)
    Synonyme
    HCN2 antikoerper, BCNG-2 antikoerper, BCNG2 antikoerper, HAC-1 antikoerper, HAC1 antikoerper, trls antikoerper, hyperpolarization activated cyclic nucleotide-gated potassium channel 2 antikoerper, hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 antikoerper, hyperpolarization-activated, cyclic nucleotide-gated K+ 2 antikoerper, LOC428335 antikoerper, HCN2 antikoerper, Hcn2 antikoerper
    Hintergrund
    Hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2) is an integral membrane protein that helps establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). Ion channels are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, hyperpolarization-activated cation channels of the HCN gene family contribute to spontaneous rhythmic activity in both the heart and brain (3).
    Gen-ID
    114244
    NCBI Accession
    NP_446136
    UniProt
    Q9JKA9
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