Transferrin Antikörper (N-Term)

Produktnummer ABIN2476916

Produktdetails anti-Transferrin Antikörper

Target: Transferrin (TF)

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Schwein, Kaninchen

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Transferrin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Functional Studies (Func)

Spezifität: Anti transferrin clone HTF-14 is specific for the N-terminal domain of human transferrin and has been shown to block binding of transferrin to the transferrin receptor (CD71). Clone HTF-14 is not able to recognise receptor bound transferrin. Clone HTF-14 recognises a conformational epitope in a loop of the N lobe of transferrin involving the critical Lys-144 residue, also essential for binding of the N lobe to the transferrin receptor (Mason et al.2009)Transferrin is a 77 kDa plasma protein synthesized by the liver involved with the transport of iron. Each transferrin molecule has two domains, both with facility to carry 2 ferric ions. The iron/transferrin complex is essential for haemoglobin synthesis and certain types of cell division.

Kreuzreaktivität: Schwein, Kaninchen, Ratte (Rattus)

Produktmerkmale: Purified IgG

Aufreinigung: Purified

Immunogen: Purified porcine transferrin

Klon: HTF-14

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Details zu Transferrin

Target: Transferrin (TF)

Andere Bezeichnung: TRANSFERRIN (TF Produkte)

Gen-ID: 7018

UniProt: P02787

Pathways: Transition Metal Ion Homeostasis