Transferrin Antikörper (N-Term)
Kurzübersicht für Transferrin Antikörper (N-Term) (ABIN2476916)
Target
Alle Transferrin (TF) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- N-Term
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Spezifität
- Anti transferrin clone HTF-14 is specific for the N-terminal domain of human transferrin and has been shown to block binding of transferrin to the transferrin receptor (CD71). Clone HTF-14 is not able to recognise receptor bound transferrin. Clone HTF-14 recognises a conformational epitope in a loop of the N lobe of transferrin involving the critical Lys-144 residue, also essential for binding of the N lobe to the transferrin receptor (Mason et al.2009)Transferrin is a 77 kDa plasma protein synthesized by the liver involved with the transport of iron. Each transferrin molecule has two domains, both with facility to carry 2 ferric ions. The iron/transferrin complex is essential for haemoglobin synthesis and certain types of cell division.
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Kreuzreaktivität
- Schwein, Kaninchen, Ratte (Rattus)
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Produktmerkmale
- Purified IgG
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Aufreinigung
- Purified
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Immunogen
- Purified porcine transferrin
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Isotyp
- IgG1
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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- Transferrin (TF)
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Andere Bezeichnung
- TRANSFERRIN
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Gen-ID
- 7018
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UniProt
- P02787
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Pathways
- Transition Metal Ion Homeostasis
Target
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