Toxin A (AA 2123-2132) Antikörper

Produktnummer ABIN2476899

Produktdetails

Target: Toxin A

Bindungsspezifität: AA 2123-2132

Reaktivität: Clostridium difficile

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: ELISA

Spezifität: This antibody is specific for Clostridium difficile Toxin A, a gram-positive motile bacterium which is the leading cause of diarrhoea in developed countries. The incidence of disease in humans varies greatly with age, spore density, and the administration of antibiotics. Toxin A (TcdA) is a large exotoxin which is an essential virulence factor for C. difficile infection. TcdA has a molecular weight of 308kD and is a glucosyltransferase, which irreversibly inactivates the Ras family of small GTPases to disrupt many important signalling pathways.

Produktmerkmale: Purified IgG

Aufreinigung: Purified

Immunogen: Synthetic peptide corresponding to the amino acids 2123-2132 of the native molecule conjugated to Keyhole limpet Haemocyanin. Peptide sequence: CTIDGKKYYFN

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 5.0 mg/mL

Referenzen

Voth, Ballard: "Clostridium difficile toxins: mechanism of action and role in disease." in: Clinical microbiology reviews, Vol. 18, Issue 2, pp. 247-63, (2005) (PubMed).

Antigendetails

Target: Toxin A

UniProt: P16154