SLIT1 Antikörper (AA 155-173)

Produktnummer ABIN2470344

Produktdetails anti-SLIT1 Antikörper

Target: SLIT1 (Slit Homolog 1 (SLIT1))

Bindungsspezifität: AA 155-173

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLIT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Slit Homolog 1 antibody was raised against amino acids 155 - 173 of Slit Homolog 1 (Mouse).

Anwendungsinformationen

Applikationshinweise: Slit Homolog 1 antibody can be used in Western Blot, and immunohistochemistry starting at 20 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies avoid freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store Slit Homolog 1 antibody at 4 °C or -20 °C.

Details zu SLIT1

Target: SLIT1 (Slit Homolog 1 (SLIT1))

Andere Bezeichnung: Slit Homolog 1 (SLIT1 Produkte)

Hintergrund: SLIT-1 (also known as KIAA0813, MEGF4, multiple epidermal growth factor-like domains 4 and Slit homolog 1 protein) is a Slit protein. This protein is a ligand for the Roundabout (Robo) receptors and acts as guidance cues in axonal migration/navigation during neural development, at the ventral midline of the neural tube. Slit1 and Slit2 are essential for midline guidance in the forebrain by acting as repulsive signals preventing inappropriate midline crossing by axons projecting from the olfactory bulb. Each SLIT gene encodes a putative secreted protein, which contains conserved protein-protein interaction domains including leucine-rich repeats and epidermal growth factor-like motifs, similar to those of the Drosophila protein. In situ hybridization studies indicated that the rat SLIT-1 mRNA was specifically expressed in the neurons of fetal and adult forebrains. This data suggests that the SLIT genes form an evolutionarily conserved group in vertebrates and invertebrates, and that the mammalian SLIT proteins may participate in the formation and maintenance of the nervous and endocrine systems by protein-protein interactions. Alternative splicing isoforms have been identified for Slit1 protein.

Gen-ID: 6585

UniProt: O75093

Pathways: Regulation of Cell Size