CRTC1 Antikörper (AA 19-34)

Produktnummer ABIN2470217

Der Kaninchen Polyklonal Anti-CRTC1-Antikörper wurde für WB, ELISA, IHC und IF validiert. Er ist geeignet, CRTC1 in Proben von Human, Maus, Ratte, Rind (Kuh), Zebrafisch (Danio rerio) und Kugelfisch zu detektieren.

Kurzübersicht für CRTC1 Antikörper (AA 19-34) (ABIN2470217)

Target: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Zebrafisch (Danio rerio), Kugelfisch

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRTC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-CRTC1 Antikörper

Bindungsspezifität: AA 19-34

Aufreinigung: Immunoaffinity Chromatography

Immunogen: CRTC1 antibody was raised against amino acids 19 - 34 of CRTC1 (Human).

Anwendungsinformationen

Applikationshinweise: CRTC1 antibody can be used in ELISA starting at 1:14000 - 1:80000, Western Blot starting at 1:100 - 1:8000, immunohistochemistry starting at 5 μg/mL, and immunofluorescence.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies avoid freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store CRTC1 antibody at 4 °C or -20 °C.

Details zu CRTC1

Target: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Andere Bezeichnung: CRTC1

Hintergrund: MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1, Transducer of regulated cAMP response element-binding protein 1, TORC1, and Transducer of CREB protein 1) is a nuclear protein that functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11,19) (q21,p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein.

Gen-ID: 23373

UniProt: Q6UUV9