CBLC Antikörper (AA 444 - 458)

Produktnummer ABIN2470158

Der Kaninchen Polyklonal anti-CBLC Antikörper (ABIN2470158) detektiert spezifisch CBLC in WB, ELISA, IHC, IP und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für CBLC Antikörper (AA 444 - 458) (ABIN2470158)

Target: CBLC (Cbl proto-oncogene C (CBLC))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBLC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Produktdetails anti-CBLC Antikörper

Bindungsspezifität: AA 444 - 458

Aufreinigung: Immunoaffinity Chromatography

Immunogen: CBLC antibody was raised against amino acids 444 - 458 of CBLC (Human).

Anwendungsinformationen

Applikationshinweise: CBLC antibody can be used in Western Blot, and immunohistochemistry starting at 10 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies avoid freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store CBLC antibody at 4 °C or -20 °C.

Details zu CBLC

Target: CBLC (Cbl proto-oncogene C (CBLC))

Andere Bezeichnung: CBLC

Hintergrund: Cbl-c is also known as signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, and RING finger protein 57. Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl-c (a.k.a. Cbl-3) is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cbl-c knock out mice show no obvious phenotype. Thus, the physiological role of Cbl-c is not known.

Gen-ID: 23624

UniProt: Q9ULV8

Pathways: EGFR Signaling Pathway