TLX1 Antikörper (AA 300-330)

Produktnummer ABIN2470149

Produktdetails anti-TLX1 Antikörper

Target: TLX1 (T-Cell Leukemia Homeobox 1 (TLX1))

Bindungsspezifität: AA 300-330

Reaktivität: Maus, Human, Ratte, Rind (Kuh), Hund, Kaninchen, Fledermaus, Affe, Huhn, Pferd, Hamster, Gibbon, Gorilla

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Protein G Column

Immunogen: TLX1 antibody was raised against amino acids 300 - 330 of TLX1 (Human).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TLX1 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, 0.2 % gelatin, 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies avoid freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: TLX1 antibody can be stored short term 4 °C. For long term storage aliquot and store at -20 °C.

Details zu TLX1

Target: TLX1 (T-Cell Leukemia Homeobox 1 (TLX1))

Andere Bezeichnung: TLX1 (TLX1 Produkte)

Synonyme: Hox-11 antikoerper, Hox11 antikoerper, HOX11 antikoerper, TCL3 antikoerper, XHox11 antikoerper, XHox11L2 antikoerper, hox11 antikoerper, tlx1-a antikoerper, TLX-1 antikoerper, RGD1563655 antikoerper, SI:dZ46P4.1 antikoerper, Tlx-1 antikoerper, ztlx-1 antikoerper, T cell leukemia, homeobox 1 antikoerper, T-cell leukemia homeobox 1 antikoerper, T-cell leukemia homeobox 1 L homeolog antikoerper, T-cell leukemia, homeobox 1 antikoerper, Tlx1 antikoerper, TLX1 antikoerper, tlx1.L antikoerper, tlx1 antikoerper

Hintergrund: HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35,q24) or t(10:14)(q24,qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.

Gen-ID: 3195

UniProt: P31314