HAVCR1 Antikörper (AA 200-300)

Produktnummer ABIN2470107

This anti-HAVCR1 antibody (ABIN2470107) is a Rabbit Polyclonal antibody detecting HAVCR1 in WB, IHC. Suitable for Human, Mouse.

Kurzübersicht für HAVCR1 Antikörper (AA 200-300) (ABIN2470107)

Target: HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HAVCR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-HAVCR1 Antikörper

Bindungsspezifität: AA 200-300

Aufreinigung: Protein G Column

Immunogen: HAVCR1 antibody was raised against amino acids 200 - 300 of HAVCR1 (Human).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: HAVCR1 antibody can be used in immunohistochemistry starting at 5 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, 0.05 % BSA, 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store HAVCR1 antibody at 4 °C for short term applications. For long term storage, aliquot and -20 °C.

Details zu HAVCR1

Target: HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))

Andere Bezeichnung: HAVCR1

Substanzklasse: Virus

Hintergrund: HAVCR1, a 359 A.A Class 1 integral membrane glycoprotein, is used by Hepatitis A virus to infect humans. It consists of a conserved N-terminal Cys-rich region, IgV (Immunoglobulin Variable region like) domain and a TSP-rich mucin domain in the extracellular region followed by a highly conserved tyrosine kinase phosphorylation motif in the cytoplasmic region. HAVCR1 is expressed on terminally differentiated CD4+ Th2 cells and regulates cytokine production. It plays an important role in the regulation of immune responses in the development of asthma and allergic responses. Its expression is critically upregulated in dedifferentiated kidney cells, thus indicating a possible role in regeneration of proximal tubule epithelium in Kidneys. HAVCR1 has shown to be upregulated in renal carcinomas, suggesting its role in tumor progression and metastasis.

Gen-ID: 26762

UniProt: Q96D42