Der Maus Monoklonal anti-CXCR4 Antikörper (Klon 12G5) (ABIN2470068) detektiert spezifisch CXCR4 in IHC, FACS und IF.
Dieser Antikörper reagiert spezifisch mit Proben aus Human, Affe, Pavian und Schimpanse.
CXCR4, a Chemokine Receptor involved in organ vascularization, neuronal cell migration, and patterning of the central nervous system during development. It binds stromal cell-derived factor 1 (SDF1, also called PBFS) and mediates migration of resting leukocytes and is unique in homing hematopoietic progenitors to bone marrow. These properties suggest that CXCR4 is involved in tumor cell migration and local tumor invasion. It is also an HIV-1 fusion co-factor that allows HIV-1 invasion in diverse human cell types. Although this receptor was initially called Neuropeptide Y3 Receptor, it does not respond to neuropeptide Y. CXCR4 has two isoforms that are produced by alternative splicing.