ITGA4 Antikörper (C-Term)

Produktnummer ABIN2469523

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ITGA4 in IHC. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Hund, Affe, Schwein, Kaninchen, Fledermaus, Hamster, Gibbon und Gorilla.

Kurzübersicht für ITGA4 Antikörper (C-Term) (ABIN2469523)

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Reaktivität: Human, Maus, Ratte, Hund, Affe, Schwein, Kaninchen, Fledermaus, Hamster, Gibbon, Gorilla

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ITGA4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-ITGA4 Antikörper

Bindungsspezifität: C-Term

Spezifität: BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Integrin alpha 4 antibody was raised against a peptide located in the C-Terminal domain of Integrin alpha 4 (Human).

Anwendungsinformationen

Applikationshinweise: Integrin alpha 4 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 5 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies avoid freeze/thaw cycles.

Lagerung: 4 °C/-80 °C

Informationen zur Lagerung: Integrin alpha 4 antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Details zu ITGA4

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Andere Bezeichnung: Integrin alpha 4

Hintergrund: ITGA4 encodes integrin alpha chain 4. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Although alpha 4 is variably cleaved to yield two unlinked chains, this cleavage is unnecessary for integrin assembly and function. Alpha 4 combines with beta 1 (ITGB1) on T-cells to form the integrin very late (activation) antigen 4 (VLA-4) that can bind to the extracellular matrix molecules fibronectin or thrombospondin, and is also a ligand for the cell surface molecule vascular cell adhesion molecule 1 (VCAM-1). In addition, alpha 4 combines with beta 7 to form the lymphocyte homing receptor known as LPAM-1 (lymphocyte Peyer Patch adhesion molecule 1). Integrins are also known to participate in cell-surface mediated signalling.

Gen-ID: 3676

UniProt: P13612

Pathways: Integrin Complex