ITGA4 Antikörper (C-Term)

Produktnummer ABIN2469523

Produktdetails anti-ITGA4 Antikörper

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Kaninchen, Affe, Hund, Schwein, Hamster, Gorilla, Fledermaus, Gibbon

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ITGA4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Spezifität: BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Integrin alpha 4 antibody was raised against a peptide located in the C-Terminal domain of Integrin alpha 4 (Human).

Anwendungsinformationen

Applikationshinweise: Integrin alpha 4 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 5 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies avoid freeze/thaw cycles.

Lagerung: 4 °C/-80 °C

Informationen zur Lagerung: Integrin alpha 4 antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Details zu ITGA4

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Andere Bezeichnung: Integrin alpha 4 (ITGA4 Produkte)

Synonyme: CD49D antikoerper, IA4 antikoerper, LOC100219853 antikoerper, integrin subunit alpha 4 antikoerper, integrin alpha 4 antikoerper, integrin subunit alpha 4 S homeolog antikoerper, ITGA4 antikoerper, Itga4 antikoerper, itga4.S antikoerper

Hintergrund: ITGA4 encodes integrin alpha chain 4. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Although alpha 4 is variably cleaved to yield two unlinked chains, this cleavage is unnecessary for integrin assembly and function. Alpha 4 combines with beta 1 (ITGB1) on T-cells to form the integrin very late (activation) antigen 4 (VLA-4) that can bind to the extracellular matrix molecules fibronectin or thrombospondin, and is also a ligand for the cell surface molecule vascular cell adhesion molecule 1 (VCAM-1). In addition, alpha 4 combines with beta 7 to form the lymphocyte homing receptor known as LPAM-1 (lymphocyte Peyer Patch adhesion molecule 1). Integrins are also known to participate in cell-surface mediated signalling.

Gen-ID: 3676

UniProt: P13612

Pathways: Integrin Complex