PDE9A Antikörper (Internal Region)

Produktnummer ABIN2469457

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PDE9A in IHC. Er zeigt eine Reaktivität gegenüber Human, Hund, Affe und Gibbon.

Kurzübersicht für PDE9A Antikörper (Internal Region) (ABIN2469457)

Target: PDE9A (phosphodiesterase 9A (PDE9A))

Reaktivität: Human, Hund, Affe, Gibbon

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE9A Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-PDE9A Antikörper

Bindungsspezifität: Internal Region

Spezifität: BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: PDE9A antibody was raised against a peptide located near the internal domain of PDE9A (Human).

Anwendungsinformationen

Applikationshinweise: PDE9A antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies avoid freeze/thaw cycles.

Lagerung: 4 °C/-80 °C

Informationen zur Lagerung: PDE9A antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Details zu PDE9A

Target: PDE9A (phosphodiesterase 9A (PDE9A))

Andere Bezeichnung: PDE9A

Hintergrund: Phosphodiesterase 9A is a cGMP-specific phosphodiesterase. PDE9A activity is inhibited by zaprinast, but it is insensitive to rolipram, vinpocetine, SKF-94120, dipyridamole, and IBMX. More than 20 alternatively spliced variants have been reported (Rentero et al. 2003). PDE9A has been implicated in penile erectile dysfunction, as well as in functional disturbances in which intraneuronal signal transmission via second messengers are important in the pathophysiology (example, bipolar affective disorder). PDE9A is the only cGMP-specific PDE with significant expression in the forebrain, and as such is likely to function in NO-cGMP signaling.

Gen-ID: 5152

UniProt: O76083