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LCK Antikörper (truncated)
LCK
Reaktivität: Human
WB, ELISA
Wirt: Maus
Monoclonal
8E5F9-4B2C7
unconjugated
Produktnummer ABIN2464076
Produktdetails anti-LCK Antikörper
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Target
Alle LCK Antikörper anzeigen
LCK
(Lymphocyte-Specific Protein tyrosine Kinase (LCK))
Bindungsspezifität
Alle Epitope für LCK Antikörper
truncated
Reaktivität
Alle Reaktivitäten für LCK Antikörper
Human
Wirt
Alle Wirte für LCK Antikörper
Maus
Klonalität
Alle Klonalitäten für LCK Antikörper
Monoklonal
Konjugat
Alle Konjugate für LCK Antikörper
Dieser LCK Antikörper ist unkonjugiert
Applikation
Alle Applikationen für LCK Antikörper
Western Blotting (WB), ELISA
Immunogen
Ni-NTA purified truncated recombinant Lck expressed in E. Coli strain BL21 (DE3).
Klon
8E5F9-4B2C7
Isotyp
IgG2a
Top Product
Discover our top product LCK Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Western Blot:1:500 - 1:2,000 ELISA:Propose dilution 1:10,000. Determining optimal working dilutions by titration test.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Buffer
Ascitic fluid containing 0.03 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Lagerung
-20 °C
Informationen zur Lagerung
Lck monoclonal antibody can be stored at -20 °C, stable for one year.
Details zu LCK
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Target
LCK
(Lymphocyte-Specific Protein tyrosine Kinase (LCK))
Andere Bezeichnung
Lck (LCK Produkte )
Synonyme
zgc:136695 antikoerper, LCK antikoerper, Hck-3 antikoerper, Lsk antikoerper, Lskt antikoerper, p56 antikoerper, p56Lck antikoerper, LSK antikoerper, YT16 antikoerper, p56lck antikoerper, pp58lck antikoerper, P56LCK antikoerper, tkl antikoerper, Lck1 antikoerper, Lcktkr antikoerper, LCK proto-oncogene, Src family tyrosine kinase antikoerper, lymphocyte protein tyrosine kinase antikoerper, lck antikoerper, LCK antikoerper, Lck antikoerper
Hintergrund
Lck(lymphocyte-specific protein tyrosine kinase), with 509-amino acid protein (about 56 kDa), belongs to the Src non-receptor tyrosine kinases family. By virtue of common structural motifs, the Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Lck is expressed predominantly in T cells and is localized to the inner surface of the plasma membrane. Lck is activated after T cell stimulation and is required for T-cell proliferation and IL-2 production. Aberrant expression or activation of Lck kinase has been reported in both lymphoid and nonlymphoid malignancies. In addition, inhibition of Lck has been a target to prevent lymphocyte activation and acute rejection.
Gen-ID
3932
UniProt
P06239
Pathways
T-Zell Rezeptor Signalweg , Fc-epsilon Rezeptor Signalübertragung , EGFR Signaling Pathway , Neurotrophin Signalübertragung , Transition Metal Ion Homeostasis , Positive Regulation of Endopeptidase Activity , CXCR4-mediated Signaling Events , Thromboxane A2 Receptor Signaling
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