ETS2 Antikörper

Produktnummer ABIN2463906

Produktdetails anti-ETS2 Antikörper

Target: ETS2 (V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (ETS2))

Reaktivität: Human, Maus, Ratte, Drosophila melanogaster

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ETS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ETS2.

Anwendungsinformationen

Applikationshinweise: ETS2 antibody can be used for detection of ETS2 by ELISA at 1:312500. ETS2 antibody can be used for detection of ETS2 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store ETS2 antibody at -20 °C.

Details zu ETS2

Target: ETS2 (V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (ETS2))

Andere Bezeichnung: ETS2 (ETS2 Produkte)

Synonyme: 0123/09 antikoerper, 0608/07 antikoerper, 0998/12 antikoerper, 3520 antikoerper, CG17077 antikoerper, CG8705 antikoerper, D-Ets-2 antikoerper, D-ets-2 antikoerper, DMPOINT1A antikoerper, Dmel\\CG17077 antikoerper, E(E2F)3D antikoerper, EK3-2 antikoerper, ETS2 antikoerper, EY3-1 antikoerper, Ets antikoerper, Ets2 antikoerper, Ets58AB antikoerper, Ets94F antikoerper, PNT-P1 antikoerper, PNTP1 antikoerper, PNTP2 antikoerper, POINT antikoerper, Pnt antikoerper, Pnt-P1 antikoerper, PntP1 antikoerper, PntP2 antikoerper, Pointed-P1 antikoerper, ets94F antikoerper, l(3)07825 antikoerper, l(3)j1B7 antikoerper, l(3)s118306 antikoerper, png antikoerper, pnt-P1 antikoerper, pnt-P2 antikoerper, pntP2 antikoerper, pntegfr antikoerper, pointed-RC antikoerper, ptd antikoerper, zgc:92106 antikoerper, wu:fe02h08 antikoerper, wu:fk74c05 antikoerper, AU022856 antikoerper, Ets-2 antikoerper, ETS2IT1 antikoerper, c-ets-2 antikoerper, pointed antikoerper, v-ets avian erythroblastosis virus E26 oncogene homolog 2 antikoerper, E26 avian leukemia oncogene 2, 3' domain antikoerper, ETS proto-oncogene 2, transcription factor antikoerper, pnt antikoerper, ets2 antikoerper, Ets2 antikoerper, ETS2 antikoerper

Hintergrund: ETS2 contains an ETS DNA-binding domain and belongs to the ETS family. ETS2 is a target of protein kinase C and upregulates GM-CSF. Ets2 and its targets play essential roles in endothelial cell function. Coexpression of Ets-2 and SRC-1 significantly associated with the rate of recurrence and HER expression in breast cancer. Overexpression of ETS2 is associated with human esophageal squamous cell carcinoma. ETS transcriptions factors, such as ETS2, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes (Dwyer et al., 2007 [PubMed 17986575]).

Molekulargewicht: 53 kDa

Gen-ID: 2114

NCBI Accession: NP_005230

UniProt: P15036

Pathways: EGFR Signaling Pathway, Myometrial Relaxation and Contraction