EGLN3 Antikörper
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- Target Alle EGLN3 Antikörper anzeigen
- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser EGLN3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Aufreinigung
- Antibody is purified by peptide affinity chromatography method.
- Immunogen
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human EGLN3.
- Top Product
- Discover our top product EGLN3 Primärantikörper
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- Applikationshinweise
- EGLN3 antibody can be used for detection of EGLN3 by ELISA at 1:1562500. EGLN3 antibody can be used for detection of EGLN3 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- Konzentration
- 1 mg/mL
- Buffer
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- Handhabung
- As with any antibody avoid repeat freeze-thaw cycles.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store EGLN3 antibody at -20 °C.
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- Target
- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
- Andere Bezeichnung
- EGLN3 (EGLN3 Produkte)
- Synonyme
- zgc:77019 antikoerper, wu:fj78a08 antikoerper, EGLN3 antikoerper, phd3 antikoerper, PHD-3 antikoerper, PHD3 antikoerper, SM-20 antikoerper, 2610021G09Rik antikoerper, AI505553 antikoerper, AI648162 antikoerper, Hif-p4h-3 antikoerper, Phd3 antikoerper, HIFP4H3 antikoerper, HIFPH3 antikoerper, egl-9 family hypoxia-inducible factor 3 antikoerper, egl-9 family hypoxia inducible factor 3 antikoerper, egl-9 family hypoxia-inducible factor 3 L homeolog antikoerper, egln3 antikoerper, EGLN3 antikoerper, egln3.L antikoerper, Egln3 antikoerper
- Hintergrund
- EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. EGLN3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. EGLN3 promotes cell death through a caspase-dependent mechanism.
- Molekulargewicht
- 27 kDa
- Gen-ID
- 112399
- NCBI Accession
- NP_071356
- UniProt
- Q9H6Z9
- Pathways
- Positive Regulation of Endopeptidase Activity
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