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RGS18 Antikörper

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RGS18 in ELISA und WB. Er zeigt eine Reaktivität gegenüber Human und Hund.
Produktnummer ABIN2462635

Kurzübersicht für RGS18 Antikörper (ABIN2462635)

Target

Alle RGS18 Antikörper anzeigen
RGS18 (Regulator of G-Protein Signalling 18 (RGS18))

Reaktivität

  • 14
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Hund

Wirt

  • 12
  • 2
  • 1
Kaninchen

Klonalität

  • 13
  • 2
Polyklonal

Konjugat

  • 11
  • 2
  • 1
  • 1
Dieser RGS18 Antikörper ist unkonjugiert

Applikation

  • 10
  • 7
  • 2
  • 1
  • 1
ELISA, Western Blotting (WB)
  • Aufreinigung

    Antibody is purified by protein A chromatography method.

    Immunogen

    Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human RGS18.
  • Applikationshinweise

    RGS18 antibody can be used for detection of RGS18 by ELISA at 1:62500. RGS18 antibody can be used for detection of RGS18 by western blot at 5.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

    Konzentration

    1 mg/mL

    Buffer

    Antibody is lyophilized in PBS buffer with 2 % sucrose.

    Handhabung

    As with any antibody avoid repeat freeze-thaw cycles.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    For short periods of storage (days) store at 4 °C. For longer periods of storage, store RGS18 antibody at -20 °C.
  • Target

    RGS18 (Regulator of G-Protein Signalling 18 (RGS18))

    Andere Bezeichnung

    RGS18

    Hintergrund

    RGS18 is a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

    Molekulargewicht

    26 kDa

    Gen-ID

    64407

    NCBI Accession

    NP_570138

    UniProt

    Q9NS28

    Pathways

    Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling
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