Klotho beta Antikörper

Produktnummer ABIN2459659

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch Klotho beta in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für Klotho beta Antikörper (ABIN2459659)

Target: Klotho beta (KLB)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Klotho beta Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Klotho beta Antikörper

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human KLB.

Anwendungsinformationen

Applikationshinweise: KLB antibody can be used for detection of KLB by ELISA at 1:12500. KLB antibody can be used for detection of KLB by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store KLB antibody at -20 °C.

Details zu Klotho beta

Target: Klotho beta (KLB)

Andere Bezeichnung: KLB

Hintergrund: KLB is a single-pass type III membrane protein. It contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. KLB is probably inactive as a glycosidase. It increases the ability of FGFR1 and FGFR4 to bind FGF21.

Molekulargewicht: 120 kDa

Gen-ID: 152831

NCBI Accession: NP_783864

UniProt: Q86Z14

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Growth Factor Binding