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Protocadherin gamma Subfamily A, 4 (PCDHGA4) Antikörper

Dieses Anti--Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von in WB und ELISA. Geeignet für Human, Maus und Ratte.
Produktnummer ABIN2459280

Kurzübersicht für Protocadherin gamma Subfamily A, 4 (PCDHGA4) Antikörper (ABIN2459280)

Target

Alle Protocadherin gamma Subfamily A, 4 (PCDHGA4) Antikörper anzeigen
Protocadherin gamma Subfamily A, 4 (PCDHGA4)

Reaktivität

  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 3
  • 1
Kaninchen

Klonalität

  • 4
Polyklonal

Konjugat

  • 4
Unkonjugiert

Applikation

Western Blotting (WB), ELISA
  • Aufreinigung

    Antibody is purified by peptide affinity chromatography method.

    Immunogen

    Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PCDHGA4.
  • Applikationshinweise

    PCDHGA4 antibody can be used for detection of PCDHGA4 by ELISA at 1:62500. PCDHGA4 antibody can be used for detection of PCDHGA4 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

    Konzentration

    1 mg/mL

    Buffer

    Antibody is lyophilized in PBS buffer with 2 % sucrose.

    Handhabung

    As with any antibody avoid repeat freeze-thaw cycles.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    For short periods of storage (days) store at 4 °C. For longer periods of storage, store PCDHGA4 antibody at -20 °C.
  • Target

    Protocadherin gamma Subfamily A, 4 (PCDHGA4)

    Andere Bezeichnung

    PCDHGA4

    Hintergrund

    PCDHGA4 is a single-pass type I membrane protein. It contains 6 cadherin domains. PCDHGA4 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

    Molekulargewicht

    86 kDa

    Gen-ID

    56111

    NCBI Accession

    NP_114442
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