PRNP Antikörper

Produktnummer ABIN2452080

Dieses Anti-PRNP-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von PRNP in WB und ELISA. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für PRNP Antikörper (ABIN2452080)

Target: PRNP (Prion Protein (PRNP))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PRNP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 2C5-5

Produktdetails anti-PRNP Antikörper

Kreuzreaktivität (Details): Does not react with mouse Prion. Not tested with other species

Aufreinigung: Purified

Sterilität: Sterile filtered

Immunogen: Recombinant human PrP lacking GPI anchor expressed and purified from rabbit kidney cell line RK13

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: 1) Western blotting: ~0. 5 g/mL
2) ELISA (most suitable)
Other applications have not been tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol

Konservierungsmittel: Azide free

Lagerung: -20 °C

Referenzen für anti-PRNP Antikörper (ABIN2452080)

Sakudo, Nakamura, Ikuta, Onodera: "Recent developments in prion disease research: diagnostic tools and in vitro cell culture models." in: The Journal of veterinary medical science / the Japanese Society of Veterinary Science, Vol. 69, Issue 4, pp. 329-37, (2007) (PubMed).

Details zu PRNP

Target: PRNP (Prion Protein (PRNP))

Andere Bezeichnung: Prion Protein

Hintergrund: Prion protein PrP is a membrane glycosylphosphatidylinositol(GPI) anchored glycoprotein highly expressed in neuron and glia cells as well as immune and reproductive cells. Mutations in the octapeptide repeat regions as well as elsewhere in this gene have been associated with neurodegenerative diseases such as Creutzfeldt Jakob disease, fatal familial insomnia, Gerstmann Straussler disease, Huntington disease like 1, and kuru. The infectious isoform of PrPC, known as PrPSc, is able to convert normal PrPPC proteins into the infectious isoform, which is insoluble amyloid aggregate, by changing their. Mature PrP protein in human consists of 209 amino acids. Several forms exist, one cell surface form anchored via and two forms, therefore multiple bands are observed in SDS-PAGE (Figure). conformation topological glycolipid transmembrane

UniProt: P04156

Pathways: Transition Metal Ion Homeostasis, Activated T Cell Proliferation