NUP98 Antikörper (AA 1-466)

Produktnummer ABIN2452066

Produktdetails anti-NUP98 Antikörper

Target: NUP98 (Nucleoporin 98kDa (NUP98))

Bindungsspezifität: AA 1-466

Reaktivität: Human, Maus, Ratte, Saccharomyces cerevisiae, Schizosaccharomyces pombe

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser NUP98 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Dot Blot (DB)

Kreuzreaktivität (Details): This antibody does not react with Tetrahymena.
Other species have not been tested.

Aufreinigung: Purified

Sterilität: Sterile filtered

Immunogen: Recombinant GST-fused human Nup98 (aa 1-466)

Klon: 2H10

Isotyp: IgG2c kappa

Anwendungsinformationen

Applikationshinweise: 1) Western blotting
2) Immunocytochemistry
3) ELISA
4) Dot blotting

Properties:
When injected into the cytoplasm, this antibody accumulates into the nuclear pores of HeLa cells and inhibits nuclear localization of endogenous Ran.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol. Azide- and carrier protein-free.

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Upon arrival centrifuge briefly and store at -20 C.

Referenzen für anti-NUP98 Antikörper (ABIN2452066)

Iwamoto, Asakawa, Ohtsuki, Osakada, Koujin, Hiraoka, Haraguchi: "Monoclonal antibodies recognize gly-leu-phe-gly repeat of nucleoporin nup98 of tetrahymena, yeasts, and humans." in: Monoclonal antibodies in immunodiagnosis and immunotherapy, Vol. 32, Issue 2, pp. 81-90, (2013) (PubMed).

Fukuhara, Ozaki, Shikata, Katahira, Yoneda, Ogino, Tachibana: "Specific monoclonal antibody against the nuclear pore complex protein, nup98." in: Hybridoma (2005), Vol. 24, Issue 5, pp. 244-7, (2005) (PubMed).

Details zu NUP98

Target: NUP98 (Nucleoporin 98kDa (NUP98))

Andere Bezeichnung: Nup98 (NUP98 Produkte)

Hintergrund: Nucleoporin 98 (Nup98) is a component of nuclear pore complex (NPC), which is a large protein assembly embedded in the nuclear envelope. It is localized on both nuclear and cytoplasmic side of NPC. This protein contains glycine-leucine-phenylalanine-glycine (GLFG) amino acid repeats and plays a critical role in nuclear trafficking. Nup98 plays a specific role in the RNA export. Nup98 gene is fused to a variety of partner genes in human myeloid and T-cell malignancies via chromosomal translocation. This hybridoma has been established by Prof. T. Tachibana's Lab. at Osaka City Univ.

UniProt: Q9HDC8

Pathways: Stem Cell Maintenance, Protein targeting to Nucleus, SARS-CoV-2 Protein Interaktom