NUP98 Antikörper (AA 1-466)

Produktnummer ABIN2452066

Dieser Ratte Monoklonal Antikörper detektiert spezifisch NUP98 in WB, ELISA, IF, ICC und DB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Saccharomyces cerevisiae und Schizosaccharomyces pombe. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für NUP98 Antikörper (AA 1-466) (ABIN2452066)

Target: NUP98 (Nucleoporin 98kDa (NUP98))

Reaktivität: Human, Maus, Ratte, Saccharomyces cerevisiae, Schizosaccharomyces pombe

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser NUP98 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Dot Blot (DB)

Klon: 2H10

Produktdetails anti-NUP98 Antikörper

Bindungsspezifität: AA 1-466

Kreuzreaktivität (Details): This antibody does not react with Tetrahymena.
Other species have not been tested.

Aufreinigung: Purified

Sterilität: Sterile filtered

Immunogen: Recombinant GST-fused human Nup98 (aa 1-466)

Isotyp: IgG2c kappa

Anwendungsinformationen

Applikationshinweise: 1) Western blotting
2) Immunocytochemistry
3) ELISA
4) Dot blotting

Properties:
When injected into the cytoplasm, this antibody accumulates into the nuclear pores of HeLa cells and inhibits nuclear localization of endogenous Ran.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol. Azide- and carrier protein-free.

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Upon arrival centrifuge briefly and store at -20 C.

Referenzen für anti-NUP98 Antikörper (ABIN2452066)

Iwamoto, Asakawa, Ohtsuki, Osakada, Koujin, Hiraoka, Haraguchi: "Monoclonal antibodies recognize gly-leu-phe-gly repeat of nucleoporin nup98 of tetrahymena, yeasts, and humans." in: Monoclonal antibodies in immunodiagnosis and immunotherapy, Vol. 32, Issue 2, pp. 81-90, (2013) (PubMed).

Fukuhara, Ozaki, Shikata, Katahira, Yoneda, Ogino, Tachibana: "Specific monoclonal antibody against the nuclear pore complex protein, nup98." in: Hybridoma (2005), Vol. 24, Issue 5, pp. 244-7, (2005) (PubMed).

Details zu NUP98

Target: NUP98 (Nucleoporin 98kDa (NUP98))

Andere Bezeichnung: Nup98

Hintergrund: Nucleoporin 98 (Nup98) is a component of nuclear pore complex (NPC), which is a large protein assembly embedded in the nuclear envelope. It is localized on both nuclear and cytoplasmic side of NPC. This protein contains glycine-leucine-phenylalanine-glycine (GLFG) amino acid repeats and plays a critical role in nuclear trafficking. Nup98 plays a specific role in the RNA export. Nup98 gene is fused to a variety of partner genes in human myeloid and T-cell malignancies via chromosomal translocation. This hybridoma has been established by Prof. T. Tachibana's Lab. at Osaka City Univ.

UniProt: Q9HDC8

Pathways: Stem Cell Maintenance, Protein targeting to Nucleus, SARS-CoV-2 Protein Interaktom