CBX5 Antikörper (AA 179-191)

Produktnummer ABIN2452033

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CBX5 in WB und IF. Er zeigt eine Reaktivität gegenüber Human und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für CBX5 Antikörper (AA 179-191) (ABIN2452033)

Target: CBX5 (Chromobox Homolog 5 (CBX5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBX5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-CBX5 Antikörper

Bindungsspezifität: AA 179-191

Kreuzreaktivität (Details): Not tested in other species.

Produktmerkmale: The product is prepared by immunizing rabbit with the synthetic peptide CEDAENKEKETAKS corresponding to the amino acid sequence 179-191 of human HP1alpha and purified by affinity purification with the peptide. The antiserum was prepared by the direction of Prof. T. Haraguchi.

Aufreinigung: Affinity purified

Sterilität: Sterile filtered

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: 1) Western blotting: 1/1,000~1/3,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.37 mg/mL

Buffer: 0.12 M sodium phosphate buffer ( pH 7.4), 50 % glycerol

Konservierungsmittel: Azide free

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: -20 C (For long term storage: -70 C)

Referenzen für anti-CBX5 Antikörper (ABIN2452033)

Lomberk, Wallrath, Urrutia: "The Heterochromatin Protein 1 family." in: Genome biology, Vol. 7, Issue 7, pp. 228, (2007) (PubMed).

Wang, Koyama, Nishida, Haraguchi, Reith, Tsukamoto: "The assembly and maintenance of heterochromatin initiated by transgene repeats are independent of the RNA interference pathway in mammalian cells." in: Molecular and cellular biology, Vol. 26, Issue 11, pp. 4028-40, (2006) (PubMed).

Kametaka, Takagi, Hayakawa, Haraguchi, Hiraoka, Yoneda: "Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 7, Issue 12, pp. 1231-42, (2002) (PubMed).

Details zu CBX5

Target: CBX5 (Chromobox Homolog 5 (CBX5))

Andere Bezeichnung: HP1 alpha/cbx5

Hintergrund: Heterochromatin protein 1 (HP1) is a major component of heterochromatin and plays a role in assembly of various proteins on chromatin and gene silencing. The HP1 family is evolutionally conserved, with members in fungi, plants and animals but not prokaryotes, and there are multiple members within the same species. The HP1 family proteins are encoded by a class of genes known as the chromobox (CBX) genes. In humans, HP1alpha is encoded by the Chromobox homolog 5 (CBX5) gene located on chromosome 12q13.13. HP1alpha has been observed to interact directly or indirectly with several non-histone proteins with a wide variety of functions.

UniProt: P45973