HCV Core Protein Antikörper (AA 13-124, AA 369-704) (Biotin)

Produktnummer ABIN2451996

Dieses Anti-HCV Core Protein-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von HCV Core Protein in ELISA, WB, IF und IHC. Geeignet für Hepatitis C Virus (HCV). Dieses Primary Antibody wurde in 5+ Publikationen zitiert.

Kurzübersicht für HCV Core Protein Antikörper (AA 13-124, AA 369-704) (Biotin) (ABIN2451996)

Target: HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))

Reaktivität: Hepatitis C Virus (HCV)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HCV Core Protein Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Klon: H6-29

Produktdetails anti-HCV Core Protein Antikörper (Biotin)

Bindungsspezifität: AA 13-124, AA 369-704

Spezifität: Specific to human HCV core antigen of genotype 1b.

Kreuzreaktivität (Details): Not tested in other genotypes.

Sterilität: Sterile filtered

Immunogen: A part of the core region (nucleotides 369-704, aa 13-124) of HCV C expressed in E. coli

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: 1. Western blotting
2. Immunohistochemistry
3. Immunofluorescence staining
4. ELISA

Kommentare:

Conjugate: Bitin conjugated, [biotin] / [IgG] = 6.6

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.7 mg/mL

Buffer: PBS, 50 % glycerol

Konservierungsmittel: Azide free

Lagerung: -20 °C

Referenzen für anti-HCV Core Protein Antikörper (Biotin) (ABIN2451996)

Brass, Moradpour, Blum: "Molecular virology of hepatitis C virus (HCV): 2006 update." in: International journal of medical sciences, Vol. 3, Issue 2, pp. 29-34, (2006) (PubMed).

Manabe, Fuke, Tanishita, Kaji, Gomi, Yoshida, Mori, Takamizawa, Yosida, Okayama: "Production of nonstructural proteins of hepatitis C virus requires a putative viral protease encoded by NS3." in: Virology, Vol. 198, Issue 2, pp. 636-44, (1994) (PubMed).

Hiramatsu, Hayashi, Haruna, Kasahara, Fusamoto, Mori, Fuke, Okayama, Kamada: "Immunohistochemical detection of hepatitis C virus-infected hepatocytes in chronic liver disease with monoclonal antibodies to core, envelope and NS3 regions of the hepatitis C virus genome." in: Hepatology (Baltimore, Md.), Vol. 16, Issue 2, pp. 306-11, (1992) (PubMed).

Takamizawa, Mori, Fuke, Manabe, Murakami, Fujita, Onishi, Andoh, Yoshida, Okayama: "Structure and organization of the hepatitis C virus genome isolated from human carriers." in: Journal of virology, Vol. 65, Issue 3, pp. 1105-13, (1991) (PubMed).

Kato, Hijikata, Ootsuyama, Nakagawa, Ohkoshi, Sugimura, Shimotohno: "Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 24, pp. 9524-8, (1991) (PubMed).

Details zu HCV Core Protein

Target: HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))

Andere Bezeichnung: HCV Core Protein

Substanzklasse: Viral Protein

Hintergrund: Hepatitis C virus (HCV) is a small (55-65 nm in size), enveloped, positive sense single-stranded RNA virus in the family Flaviviridae and the principal cause of parenteral non-A, non-B hepatitis. The virus genome consists of a single open reading frame of approximately 9,4 kb which encodes a single polyprotein of about 3,010 amino acids. The polyprotein is processed by host cell and viral proteases into four structural proteins (core, envelope1 and 2, and p7) and six non-structural proteins (NS2, 3, 4a, 4b, 5a, and 5b) necessary for viral replication. HCV core protein is not only a component of nucleocapsid but also has multiple functions and is a pathogenic factor for hepatitis. It also participates in some cellular processes, including transcriptional regulation and cellular transduction. HCV core antigen is used as diagnostic marker for HCV infection.