GLO1 Antikörper (full length)

Produktnummer ABIN2451990

Produktdetails anti-GLO1 Antikörper

Target: GLO1 (Glyoxalase I (GLO1))

Bindungsspezifität: full length

Reaktivität: Human, Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser GLO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunochromatography (IC)

Spezifität: Specific to human, simian, and mouse glyoxalase I.

Kreuzreaktivität (Details): Not tested in other species.

Produktmerkmale: The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.

Aufreinigung: Purified

Sterilität: Sterile filtered

Immunogen: Recombinant GST-fused mouse glyoxalase I (full length)

Klon: 6F10

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: 1. Western blotting: ~ 1,000
2. Immunocytochemistry
3. ELISA
Other applications are not tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol

Konservierungsmittel: Azide free

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: -20 C (For long term storage: -70 C)

Referenzen für anti-GLO1 Antikörper (ABIN2451990)

Hovatta, Tennant, Helton, Marr, Singer, Redwine, Ellison, Schadt, Verma, Lockhart, Barlow: "Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice." in: Nature, Vol. 438, Issue 7068, pp. 662-6, (2005) (PubMed).

Chen, Wollmer, Hoerndli, Münch, Kuhla, Rogaev, Tsolaki, Papassotiropoulos, Götz: "Role for glyoxalase I in Alzheimer's disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 20, pp. 7687-92, (2004) (PubMed).

Junaid, Kowal, Barua, Pullarkat, Sklower Brooks, Pullarkat: "Proteomic studies identified a single nucleotide polymorphism in glyoxalase I as autism susceptibility factor." in: American journal of medical genetics. Part A, Vol. 131, Issue 1, pp. 11-7, (2004) (PubMed).

Details zu GLO1

Target: GLO1 (Glyoxalase I (GLO1))

Andere Bezeichnung: Glyoxalase 1 (GLO1) (GLO1 Produkte)

Synonyme: GLOD1 antikoerper, GLYI antikoerper, 0610009E22Rik antikoerper, 1110008E19Rik antikoerper, 2510049H23Rik antikoerper, AW550643 antikoerper, GLY1 antikoerper, Glo-1 antikoerper, Glo-1r antikoerper, Glo-1s antikoerper, Glo1-r antikoerper, Glo1-s antikoerper, Qglo antikoerper, cb554 antikoerper, zgc:66035 antikoerper, wu:fb82g09 antikoerper, glod1 antikoerper, glyi antikoerper, glo1 antikoerper, GLO1 antikoerper, ATGLX1 antikoerper, F12F1.32 antikoerper, F12F1_32 antikoerper, GLYOXALASE I antikoerper, glyoxalase I homolog antikoerper, trypanothione-dependent glyoxalase I antikoerper, glyoxalase I antikoerper, glyoxalase 1 antikoerper, glyoxalase 1 L homeolog antikoerper, glyoxalase 1 S homeolog antikoerper, lactoylglutathione lyase antikoerper, glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein antikoerper, GLO1 antikoerper, Glo1 antikoerper, glo1 antikoerper, glo1.L antikoerper, glo1.S antikoerper, GST3 antikoerper, GLX1 antikoerper, STY1687 antikoerper, Bcen_2094 antikoerper, gloA antikoerper

Hintergrund: Glyoxalase I (GLO1) is an enzyme that plays a role in the detoxification of methylglyoxal (MG), a side-product of glycolysis, via condensation with glutathione to produce S-lactoyl-glutathione. GLO1 is a zinc metalloenzyme whose crystal structure has been solved. The bacterial and yeast enzymes are monomeric while the mammalian one is homodimeric and its sequence is well conserved. GLO1 is found over-expressed in some tumors. GLO1 has also been suggested to be involved in anxiety diseases, autism, and Alzheimer's disease.

UniProt: Q9CPU0