GLO1 Antikörper (full length)

Produktnummer ABIN2451990

This anti-GLO1 antibody (ABIN2451990) is a Rat Monoclonal antibody detecting GLO1 in WB, ELISA, IF, IC. Suitable for Human, Mouse.

Kurzübersicht für GLO1 Antikörper (full length) (ABIN2451990)

Target: GLO1 (Glyoxalase I (GLO1))

Reaktivität: Human, Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser GLO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunochromatography (IC)

Klon: 6F10

Produktdetails anti-GLO1 Antikörper

Bindungsspezifität: full length

Spezifität: Specific to human, simian, and mouse glyoxalase I.

Kreuzreaktivität (Details): Not tested in other species.

Produktmerkmale: The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.

Aufreinigung: Purified

Sterilität: Sterile filtered

Immunogen: Recombinant GST-fused mouse glyoxalase I (full length)

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: 1. Western blotting: ~ 1,000
2. Immunocytochemistry
3. ELISA
Other applications are not tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol

Konservierungsmittel: Azide free

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: -20 C (For long term storage: -70 C)

Referenzen für anti-GLO1 Antikörper (ABIN2451990)

Hovatta, Tennant, Helton, Marr, Singer, Redwine, Ellison, Schadt, Verma, Lockhart, Barlow: "Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice." in: Nature, Vol. 438, Issue 7068, pp. 662-6, (2005) (PubMed).

Chen, Wollmer, Hoerndli, Münch, Kuhla, Rogaev, Tsolaki, Papassotiropoulos, Götz: "Role for glyoxalase I in Alzheimer's disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 20, pp. 7687-92, (2004) (PubMed).

Junaid, Kowal, Barua, Pullarkat, Sklower Brooks, Pullarkat: "Proteomic studies identified a single nucleotide polymorphism in glyoxalase I as autism susceptibility factor." in: American journal of medical genetics. Part A, Vol. 131, Issue 1, pp. 11-7, (2004) (PubMed).

Details zu GLO1

Target: GLO1 (Glyoxalase I (GLO1))

Andere Bezeichnung: Glyoxalase 1 (GLO1)

Hintergrund: Glyoxalase I (GLO1) is an enzyme that plays a role in the detoxification of methylglyoxal (MG), a side-product of glycolysis, via condensation with glutathione to produce S-lactoyl-glutathione. GLO1 is a zinc metalloenzyme whose crystal structure has been solved. The bacterial and yeast enzymes are monomeric while the mammalian one is homodimeric and its sequence is well conserved. GLO1 is found over-expressed in some tumors. GLO1 has also been suggested to be involved in anxiety diseases, autism, and Alzheimer's disease.

UniProt: Q9CPU0