GRK4 Antikörper

Produktnummer ABIN2428193

Der Kaninchen Polyklonal Anti-GRK4 Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, GRK4 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für GRK4 Antikörper (ABIN2428193)

Target: GRK4 (G Protein-Coupled Receptor Kinase 4 (GRK4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRK4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-GRK4 Antikörper

Aufreinigung: Antigen affinity purification

Immunogen: Recombinant protein of human GRK4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Handhabung: Avoid freeze / thaw cycles.

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: Store at -20°C (regular) and -80°C (long term).

Details zu GRK4

Target: GRK4 (G Protein-Coupled Receptor Kinase 4 (GRK4))

Andere Bezeichnung: GRK4

Hintergrund: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin, the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.
Synonyms: IT11, GPRK4, GRK4a, GPRK2L

Molekulargewicht: Calculated MW: 67 kDa

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling