GDF15 Antikörper (N-Term)

Produktnummer ABIN238331

Der Maus Monoklonal Anti-GDF15-Antikörper wurde für FACS und cELISA validiert. Er ist geeignet, GDF15 in Proben von Human zu detektieren.

Kurzübersicht für GDF15 Antikörper (N-Term) (ABIN238331)

Target: GDF15 (Growth Differentiation Factor 15 (GDF15))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GDF15 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Cell-ELISA (cELISA)

Klon: ME-6D10

Produktdetails anti-GDF15 Antikörper

Bindungsspezifität: AA 30-194, N-Term

Aufreinigung: Protein G

Immunogen: genetic immunisation with cDNA encoding aa30-194 (N-term) of MIC-1 proprotein

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Kommentare:

Synonyms: GDF15

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, pH 7.2

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C

Informationen zur Lagerung: short term: 2 °C - 8 °C, long term: -20 °C

Details zu GDF15

Target: GDF15 (Growth Differentiation Factor 15 (GDF15))

Andere Bezeichnung: MIC-1

Hintergrund: Macrophage inhibitory cytokine-1 (MIC-1) is a member of the transforming growth factor-ß superfamily that regulates a wide variety of physiological processes involved in tissue differentiation and maintenance. MIC-1 is synthesized as a 62-kDa intracellular protein, which, after cleavage by a furin like protease, is secreted as a 25-kDa disulphide-linked dimeric protein. Expression of MIC-1 results in inhibition of macrophage activation, regulated by the p53 pathway, in response to pro-inflammatory monokines. MIC-1 is involved in tumour pathogenesis and its measurement can be used as a clinical tool for the diagnosis of a wide range of cancers. It could be a useful marker for aggressive prostate cancer while MIC-1 is upregulated in advanced and more aggressive prostatic tumours.

UniProt: Q99988

Pathways: SARS-CoV-2 Protein Interaktom