THRA Antikörper (N-Term)

Produktnummer ABIN233838

Produktdetails anti-THRA Antikörper

Target: THRA (Thyroid Hormone Receptor, alpha (THRA))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser THRA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: This product was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody reacts with human THRA protein.  A BLAST analysis was used to suggest cross-reactivity with THRA from mouse, human and rat based on a 100% homology with the immunizing sequence.  Cross-reactivity with THRA from other sources has not been determined.

Produktmerkmale: This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. Thyroid hormone receptor alpha is a nuclear hormone receptor with high affinity for the hormone triiodo-thyronine. THRA is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having a certain extent of redundancy, may mediate different functions of thyroid hormone. THRA interacts with NCOA3 and NCOA6 co-activators, leading to a strong increase in transcription of target genes. THRA is localized within the nucleus and has been found to exist as 4 isoforms originating from alternative splicing variants. This antibody recognizes THRA isoform 1. Isoform 1 has a distinct C-terminus compared to isoform 2.

Aufreinigung: affinity purified

Sterilität: Sterile filtered

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the amino terminus of human THRA isoform 1 protein.
Immunogen Type: Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity purified antibody has been tested for use in ELISA and western blotting.

Kommentare:

Gene Name: THRA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.89 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is three (3) months from date of opening.

Haltbarkeit: 3 months

Referenzen für anti-THRA Antikörper (ABIN233838)

Contreras-Jurado, García-Serrano, Martínez-Fernández, Ruiz-Llorente, Paramio, Aranda: "Impaired hair growth and wound healing in mice lacking thyroid hormone receptors." in: PLoS ONE, Vol. 9, Issue 9, pp. e108137, (2015) (PubMed).

Mishra, Zhu, Ge, Cheng: "Adipogenesis is differentially impaired by thyroid hormone receptor mutant isoforms." in: Journal of molecular endocrinology, Vol. 44, Issue 4, pp. 247-55, (2010) (PubMed).

Details zu THRA

Target: THRA (Thyroid Hormone Receptor, alpha (THRA))

Andere Bezeichnung: THRA (THRA Produkte)

Synonyme: AR7 antikoerper, CHNG6 antikoerper, EAR7 antikoerper, ERB-T-1 antikoerper, ERBA antikoerper, ERBA1 antikoerper, NR1A1 antikoerper, THRA1 antikoerper, THRA2 antikoerper, c-ERBA-1 antikoerper, C-ERBA-ALPHA antikoerper, TRalpha antikoerper, c-erba antikoerper, erba antikoerper, nr1a1-A antikoerper, thra-A antikoerper, thra1 antikoerper, TR[a]1 antikoerper, nr1a1 antikoerper, thra antikoerper, thral antikoerper, tra antikoerper, tra1 antikoerper, wu:fb59g07 antikoerper, Thra1 antikoerper, 6430529J03Rik antikoerper, AW259572 antikoerper, Erba antikoerper, Nr1a1 antikoerper, Rvr antikoerper, T3R[a] antikoerper, T3Ralpha antikoerper, Thra2 antikoerper, C-ERBA ALPHA1 antikoerper, Thra antikoerper, fTHRalphaA antikoerper, nr1a1-a antikoerper, thyroid hormone receptor, alpha antikoerper, thyroid hormone receptor, alpha L homeolog antikoerper, thyroid hormone receptor alpha a antikoerper, thyroid hormone receptor alpha antikoerper, thyroid hormone receptor alpha-A antikoerper, THRA antikoerper, thra.L antikoerper, thraa antikoerper, Thra antikoerper, tr-alpha antikoerper, LOC109641414 antikoerper

Hintergrund: This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Thyroid hormone receptor alpha is a nuclear hormone receptor with high affinity for the hormone triiodo-thyronine.  THRA is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having a certain extent of redundancy, may mediate different functions of thyroid hormone.  THRA interacts with NCOA3 and NCOA6 co-activators, leading to a strong increase in transcription of target genes. THRA is localized within the nucleus and has been found to exist as 4 isoforms originating from alternative splicing variants.  Isoform 1 has a distinct C-terminus compared to isoform 2.
Synonyms: Thyroid hormone receptor alpha Nuclear receptor subfamily 1 group A member 1 c-erbA-alpha c-erbA-1 V-erbA-related protein 7 EAR-7

Gen-ID: 7067, 40806160

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Maintenance of Protein Location, Skeletal Muscle Fiber Development