CHID1 Antikörper

Produktnummer ABIN2192225

Produktdetails anti-CHID1 Antikörper

Target: CHID1 (Chitinase Domain Containing 1 (CHID1))

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CHID1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Sterilität: 0.2 μm filtered

Klon: 1C11

Anwendungsinformationen

Applikationshinweise: The typical starting working dilution is 1:50. Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Haltbarkeit: 12 months

Referenzen für anti-CHID1 Antikörper (ABIN2192225)

Kzhyshkowska, Mamidi, Gratchev, Kremmer, Schmuttermaier, Krusell, Haus, Utikal, Schledzewski, Scholtze, Goerdt: "Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway." in: Blood, Vol. 107, Issue 8, pp. 3221-8, (2006) (PubMed).

Details zu CHID1

Target: CHID1 (Chitinase Domain Containing 1 (CHID1))

Andere Bezeichnung: Stabilin-1 Interacting Chitinase-Like Protein (CHID1 Produkte)

Hintergrund: The monoclonal antibody 1C11 recognizes human stabilin-1 interacting chitinase-like protein (SI-CLP). SI-CLP is a 39 kD member of the family of Glyco_18-domain-containing proteins. These chitinase-like proteins are involved primarily in Th2-associated disorders and tumor progression. Chitinase-like proteins are soluble mediators of cell differentiation, proliferation, activation, migration, and adherence. Chitinase like protein SI-CLP is a stabilin-1 interacting partner. SI-CLP gene expression was up- regulated by IL-4 and dexamethasone on the mRNA and protein levels in primary human macrophages in parallel with the expression of stabilin-1. The major site of SI-CLP intracellular localization is in Lamp1-positive and secretion commited CD63+ secretory lysosomes. The endocytic/sorting receptor stabilin-1 is a highly specific intracellular sorting receptor for SI-CLP. SI-CLP directly binds to, and colocalizes with stabilin-1. The lysosomal localization of SI-CLP in stabilin-1-negative macrophages, however, indicates that stabilin-1 may not be the only receptor mediating trafficking of newly synthesized SI-CLP. In vivo, the monoclonal antibody 1C11 recognizes SI-CLP in the cellular fraction of bronchoalveolar lavage specimens obtained from patients with chronic inflammatory disorders of the respiratory tract and in peripheral-blood leukocytes (PBLs) from these patients as well as healthy donors. Immunogen Amino acids 24 to 73 fragment GST-fusion protein Rat IgG2a