Lactoferrin Antikörper

Produktnummer ABIN2192193

Produktdetails anti-Lactoferrin Antikörper

Target: Lactoferrin (LTF) (Lactotransferrin (LTF))

Reaktivität: Human

Wirt: Cow

Klonalität: Polyklonal

Konjugat: Dieser Lactoferrin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunoassay (IA)

Sterilität: 0.2 μm filtered

Anwendungsinformationen

Applikationshinweise: For Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Haltbarkeit: 12 months

Referenzen für anti-Lactoferrin Antikörper (ABIN2192193)

van Veen, Geerts, van Berkel, Nuijens: "Analytical cation-exchange chromatography to assess the identity, purity, and N-terminal integrity of human lactoferrin." in: Analytical biochemistry, Vol. 309, Issue 1, pp. 60-6, (2002) (PubMed).

Nibbering, Ravensbergen, Welling, van Berkel, van Berkel, Pauwels, Nuijens: "Human lactoferrin and peptides derived from its N terminus are highly effective against infections with antibiotic-resistant bacteria." in: Infection and immunity, Vol. 69, Issue 3, pp. 1469-76, (2001) (PubMed).

Nuijens, van Berkel, Geerts, Hartevelt, de Boer, van Veen, Pieper: "Characterization of recombinant human lactoferrin secreted in milk of transgenic mice." in: The Journal of biological chemistry, Vol. 272, Issue 13, pp. 8802-7, (1997) (PubMed).

Details zu Lactoferrin

Target: Lactoferrin (LTF) (Lactotransferrin (LTF))

Andere Bezeichnung: Lactoferrin (LTF Produkte)

Synonyme: LTF antikoerper, GIG12 antikoerper, HLF2 antikoerper, LF antikoerper, Lf antikoerper, Csp82 antikoerper, MMS10R antikoerper, Ms10r antikoerper, PLF antikoerper, TFEW antikoerper, conalbumin antikoerper, lactotransferrin antikoerper, transferrin antikoerper, transferrin (ovotransferrin) antikoerper, LTF antikoerper, CpipJ_CPIJ000114 antikoerper, TF antikoerper, Ltf antikoerper

Hintergrund: Human lactoferrin (LF) is an 80 kDa glycoprotein which was first isolated from human milk. It plays an important part in the immune system and helps to fight infections. Lactoferrin promotes the health of the gastro-intestinal system by improving the intestinal microbial balance. In addition, LF can be found in epithelia and most body fluids and secretions. Lactoferrin is secreted in plasma by neutrophils. Its plasma concentration also represents a positive relation to the total pool of neutrophils and the rate of neutrophil turnover. In inflammation lactoferrin is released from secondary granules of neutrophilic leukocytes into the extracellular medium. Therefore the extracellular lactoferrin concentration can be used as an index for neutrophil activation. Lactoferrin strongly binds to iron and this iron binding property is considered to be an important antimicrobial. Human lactoferrin binds to bacterial products through its highly positively charged N- terminus, it kills various bacteria, most probably by inducing intracellular changes in these bacteria without affecting the membrane permeability. Cleavage by pepsin of lactoferrin leads to the release of lactoferricin H. This 47 amino acid peptide has more antimicrobial activity than its precursor and it can inhibit the classical but not the alternative complement pathway. Lactoferrin also plays a role in signal transduction, immunomodulation and has antiadhesive, anticancer, antiviral activity.

Pathways: Transition Metal Ion Homeostasis