Telefon:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antikoerper-online.de

ELANE Antikörper (Elastase, Neutrophil Expressed) Primary Antibody

ELANE Reaktivität: Human IA Wirt: Kaninchen Polyclonal unconjugated
Pubmed (2 Referenzen)
Produktnummer ABIN2192191
$729.45
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 6 bis 8 Werktagen
  • Target Alle ELANE Antikörper anzeigen
    ELANE
    Reaktivität
    • 83
    • 21
    • 20
    • 1
    • 1
    Human
    Wirt
    • 64
    • 21
    • 4
    • 2
    Kaninchen
    Klonalität
    • 62
    • 29
    Polyklonal
    Konjugat
    • 47
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ELANE Antikörper ist unkonjugiert
    Applikation
    • 42
    • 42
    • 25
    • 19
    • 13
    • 11
    • 9
    • 7
    • 7
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Immunoassay (IA)
    Sterilität
    0.2 μm filtered
  • Applikationshinweise
    The antibody can be used in immuno assays. The antibody is not useful in immuno histology.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    Haltbarkeit
    12 months
  • Hiltermann, Lapperre, van Bree, Steerenberg, Brahim, Sont, Sterk, Hiemstra, Stolk: "Ozone-induced inflammation assessed in sputum and bronchial lavage fluid from asthmatics: a new noninvasive tool in epidemiologic studies on air pollution and asthma." in: Free radical biology & medicine, Vol. 27, Issue 11-12, pp. 1448-54, (2000) (PubMed).

    Dentener, Francot, Hiemstra, Tool, Verhoeven, Vandenabeele, Buurman: "Bactericidal/permeability-increasing protein release in whole blood ex vivo: strong induction by lipopolysaccharide and tumor necrosis factor-alpha." in: The Journal of infectious diseases, Vol. 175, Issue 1, pp. 108-17, (1997) (PubMed).

  • Target
    ELANE
    Andere Bezeichnung
    Leukocyte Elastase (ELANE Produkte)
    Synonyme
    ELA2, GE, HLE, HNE, NE, PMN-E, SCN1, Ela2, F430011M15Rik, ela2, ELANE, elastase, neutrophil expressed, proteinase 3, ELANE, Elane, prtn3
    Hintergrund
    Leukocyte elastase, a major serine proteinase in man, is predominantly present in the azurophilic granules of neutrophils and monocytes. Elastase has a broad range of extracellular matrix substrates including elastin, proteoglycans, collagen and fibronectin. The action of elastase is controlled by serine proteinase inhibitors. Elastase, when released during inflammation, is rapidly bound by its two main inhibitors, alpha1- PI and alpha2-macroglobuline to form elastase-inhibitor complexes. In addition mucosa secretions may contain the locally secreted elastase inhibitors elafin/SKALP and SLPI. When secreted at sites of inflammation elastase can cause severe tissue damage. An important role has been suggested for human elastase in various inflammatory disorders, including pulmonary emphysema, sepsis, arthritis, nephritis and certain skin diseases. Elastase induces the production of IL-8 in human bronchial epithelial, a proces that occurs in part through TLR4.
Sie sind hier:
Kundenservice